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SPR741 acetate

Name: SPR741 acetate
Brand: TargetMol
SKU: T12992
Price: 110 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12992

Alias SPR741 acetate (1179330-52-9 free base), SPR741 acetate, NAB741 acetate

SPR741 acetate is a cationic peptide derived from polymyxin B. It exhibits antimicrobial activity against gram-negative bacteria by inhibiting severe gram-negative bacterial sensory by increasing the permeability of the outer membrane of gram-negative bacteria.SPR741 acetate is often used in conjunction with antibiotics for the treatment of a number of diseases.

SPR741 acetate

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Purity: 98.57%

Catalog No. T12992Alias SPR741 acetate (1179330-52-9 free base), SPR741 acetate, NAB741 acetate

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$110	-	In Stock
5 mg	$279	-	In Stock
10 mg	$380	-	In Stock
25 mg	$592	-	In Stock
50 mg	$816	-	In Stock
100 mg	$1,090	-	In Stock
200 mg	$1,480	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.57%

Appearance:Solid

Color:White

Resource Download

COA HPLC MS

Product Introduction

Bioactivity

Description	SPR741 acetate is a cationic peptide derived from polymyxin B. It exhibits antimicrobial activity against gram-negative bacteria by inhibiting severe gram-negative bacterial sensory by increasing the permeability of the outer membrane of gram-negative bacteria.SPR741 acetate is often used in conjunction with antibiotics for the treatment of a number of diseases.
In vitro	SPR741 acetate potentiates antibiotics ,SPR741 acetate are substrates of the AcrAB-TolC efflux pump in E. coli, effectively circumventing the contribution of this pump to intrinsic antibiotic resistance. The intrinsic resistance of E. coli to certain antibiotics that is mediated by both the outer membrane and the AcrAB-TolC efflux system can be overcome, or circumvented, by combining the antibiotic with SPR741 acetate but that potentiation of intrinsic resistance due primarily to efflux may be limited.[1]
In vivo	SPR741 acetate has the ability to permeabilize the outer membrane of Gram-negative bacteria, thus makeing them sensitive to hydrophobic antibiotics. SPR741 acetate has a significantly safety profile of compared to that of polymyxin B, which suffers severe, dose-limiting nephrotoxicity in humans. Polymyxin B exhibited nephrotoxicity at a far-lower exposure-normalized dose than SPR741 acetate in multiday rodent and nonhuman primate studies.[1]
Synonyms	SPR741 acetate (1179330-52-9 free base), SPR741 acetate, NAB741 acetate

Chemical Properties

Molecular Weight	1052.18
Formula	C₄₆H₇₇N₁₃O₁₅
Smiles	C[C@@H](O)[C@H]1C(NCC[C@H](NC([C@H](NC([C@@H](NC(C)=O)[C@H](O)C)=O)CO)=O)C(N[C@@H](CCN)C(N[C@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](CCN)C(N[C@@H](CCN)C(N1)=O)=O)=O)=O)=O)=O)=O.CC(O)=O
Relative Density.	no data available
Sequence	Ac-Thr-D-Ser-Dab(1)-Dab-D-Phe-Leu-Dab-Dab-Thr-(1)

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 117 mg/mL (111.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9504 mL	4.7520 mL	9.5041 mL	47.5204 mL
5 mM	0.1901 mL	0.9504 mL	1.9008 mL	9.5041 mL
10 mM	0.0950 mL	0.4752 mL	0.9504 mL	4.7520 mL
20 mM	0.0475 mL	0.2376 mL	0.4752 mL	2.3760 mL
50 mM	0.0190 mL	0.0950 mL	0.1901 mL	0.9504 mL
100 mM	0.0095 mL	0.0475 mL	0.0950 mL	0.4752 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc