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Anti-TPX2 Antibody (5B212)
😃Good
Catalog No. TMAB-13710
Anti-TPX2 Antibody (5B212) is a Mouse antibody targeting TPX2. Anti-TPX2 Antibody (5B212) can be used in WB.
Anti-TPX2 Antibody (5B212)
Anti-TPX2 Antibody (5B212)
😃Good
Catalog No. TMAB-13710
Anti-TPX2 Antibody (5B212) is a Mouse antibody targeting TPX2. Anti-TPX2 Antibody (5B212) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-TPX2 Antibody (5B212) is a Mouse antibody targeting TPX2. Anti-TPX2 Antibody (5B212) can be used in WB. |
| Ig Type | IgG1, k |
| Clone | 5B212 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. |
| Tissue Specificity | Expressed in lung carcinoma cell lines but not in normal lung tissues. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | TPX2 is essential for spindle pole and mitotic spindle formulation, playing a role in the S and G2 phases of mitosis. It is also critical for the function of protein kinase Aurora A. TPX2 autophosphorylates Aurora A, targeting it to the spindle apparatus and allowing it to function in eukaryotic meiotic and mitotic cell cycles. TPX2 has also been found to be highly expressed in cancer cells. |
| Immunogen | Recombinant Protein: human TPX2 between 1-531 amino acids |
| Antigen Species | Human |
| Gene Name | TPX2 |
| Gene ID | |
| Protein Name | Targeting protein for Xklp2 |
| Uniprot ID | |
| Function | Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. |
| Molecular Weight | Theoretical: 86 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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