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Anti-Ferritin light chain Antibody (6N112) (Synonyms: NBIA3, MGC71996, LFTD, ferritin, light polypeptide)

Catalog No. TMAC-01458 Copy Product Info
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Anti-Ferritin light chain Antibody (6N112) is a Rabbit antibody targeting Ferritin light chain. Anti-Ferritin light chain Antibody (6N112) can be used in ICC/IF,WB.

Anti-Ferritin light chain Antibody (6N112)

Copy Product Info
🥰Excellent
Catalog No. TMAC-01458
Synonyms NBIA3, MGC71996, LFTD, ferritin, light polypeptide

Anti-Ferritin light chain Antibody (6N112) is a Rabbit antibody targeting Ferritin light chain. Anti-Ferritin light chain Antibody (6N112) can be used in ICC/IF,WB.

Anti-Ferritin light chain Antibody
(6N112)
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2977-10 days7-10 days
100 μL$4967-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-Ferritin light chain Antibody (6N112) is a Rabbit antibody targeting Ferritin light chain. Anti-Ferritin light chain Antibody (6N112) can be used in ICC/IF,WB.
SynonymsNBIA3, MGC71996, LFTD, ferritin, light polypeptide
Ig Type
IgG
Clone
6N112
Reactivity
Human,Mouse,Rat,zebrafish
Verified Activity
1. Western blot analysis of Ferritin on zebrafish lysates using anti-Ferritin antibody at 1/1,000 dilution.
2. Western blot analysis of Ferritin on hybrid fish (crucian-carp) liver tissue lysate using anti-Ferritin antibody at 1/500 dilution.
3. ICC staining Ferritin in SHG-44 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. ICC staining Ferritin in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
5. ICC staining Ferritin in SH-SY-5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
verifiedActivityverifiedActivityverifiedActivityverifiedActivityverifiedActivity
Application
Recommended Dose
WB: 1:500-1000; ICC/IF: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundMammalian ferritins consist of 24 subunits made up of two types of polypeptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts. The gene encoding human ferritin heavy chain maps to chromosome 11q13 and the human ferritin light chain gene maps to chromosome 19q13.3-q13.4.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 21 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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