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TFEB activator 1

Name: TFEB activator 1
Brand: TargetMol
SKU: T8055
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T8055Cas No. 39777-61-2

Alias RPN77612, Curcumin analog compound C1, Curcumin analog C1, (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,

TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's disease.

TFEB activator 1

🥰Excellent

Purity: 98.87%

Catalog No. T8055Alias RPN77612, Curcumin analog compound C1, Curcumin analog C1, (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,Cas No. 39777-61-2

TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's disease.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$57	In Stock	In Stock
10 mg	$85	In Stock	In Stock
25 mg	$166	In Stock	In Stock
50 mg	$288	In Stock	In Stock
100 mg	$450	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.87%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's disease.
Targets&IC50	Flag-TFEB nuclear translocation:2167 nM (EC50)
Synonyms	RPN77612, Curcumin analog compound C1, Curcumin analog C1, (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,

Chemical Properties

Molecular Weight	294.34
Formula	C₁₉H₁₈O₃
Cas No.	39777-61-2
Smiles	COc1ccccc1\C=C\C(=O)\C=C\c1ccccc1OC
Relative Density.	1.128 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 127.5 mg/mL (433.17 mM), Sonication is recommended.

Ethanol: 2 mg/mL (6.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (16.99 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3974 mL	16.9872 mL	33.9743 mL	169.8716 mL
5 mM	0.6795 mL	3.3974 mL	6.7949 mL	33.9743 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.3397 mL	1.6987 mL	3.3974 mL	16.9872 mL
20 mM	0.1699 mL	0.8494 mL	1.6987 mL	8.4936 mL
50 mM	0.0679 mL	0.3397 mL	0.6795 mL	3.3974 mL
100 mM	0.0340 mL	0.1699 mL	0.3397 mL	1.6987 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc