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TFEB activator 1

Name: TFEB activator 1
Brand: TargetMol
SKU: T8055
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8055Cas No. 39777-61-2

Alias RPN77612, Curcumin analog compound C1, Curcumin analog C1, (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,

TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's disease.

TFEB activator 1

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Purity: 98.87%

Catalog No. T8055Alias RPN77612, Curcumin analog compound C1, Curcumin analog C1, (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,Cas No. 39777-61-2

TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's disease.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$57	In Stock	In Stock
10 mg	$85	In Stock	In Stock
25 mg	$166	In Stock	In Stock
50 mg	$288	In Stock	In Stock
100 mg	$450	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.87%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

TFEB activator 1 AI Summary

TFEB activator 1 demonstrates significant cytotoxicity against various human cancer cell lines, including KB, HL60, HeLa, HCT116, MDA-MB-231, and RPMI-7951 cells, highlighted by IC50 and GI50 values. For example, it has a GI50 value of 4000.0 nM against HCT116 cells after 48 hours, and GI50 values of 1000.0 nM and 2300.0 nM against MDA-MB-231 and RPMI-7951 cells, respectively, after 72 hours. It also exhibits antiplasmodial activity with an IC50 value of 74740.0 nM against the blood stage of chloroquine-sensitive Plasmodium falciparum 3D7. Additionally, TFEB activator 1 activates Nrf2 in human HepG2 cells, significantly increasing ARE-driven luciferase reporter gene expression, with a fold change of 60.3 at 15 µM after 5 hours and an EC50 of 3300.0 nM. However, the compound shows low hydrolytic stability, indicating substantial degradation after 45 hours in a specific solution..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's disease.
Targets&IC50	Flag-TFEB nuclear translocation:2167 nM (EC50)
Synonyms	RPN77612, Curcumin analog compound C1, Curcumin analog C1, (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,

Chemical Properties

Molecular Weight	294.34
Formula	C₁₉H₁₈O₃
Cas No.	39777-61-2
Smiles	COc1ccccc1\C=C\C(=O)\C=C\c1ccccc1OC
Relative Density.	1.128 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 127.5 mg/mL (433.17 mM), Sonication is recommended.

Ethanol: 2 mg/mL (6.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (16.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3974 mL	16.9872 mL	33.9743 mL	169.8716 mL
5 mM	0.6795 mL	3.3974 mL	6.7949 mL	33.9743 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.3397 mL	1.6987 mL	3.3974 mL	16.9872 mL
20 mM	0.1699 mL	0.8494 mL	1.6987 mL	8.4936 mL
50 mM	0.0679 mL	0.3397 mL	0.6795 mL	3.3974 mL
100 mM	0.0340 mL	0.1699 mL	0.3397 mL	1.6987 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc