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Anti-TREM-2 Antibody-HRP (4H451)
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Catalog No. TMAY-01617H
Alias triggering receptor expressed on myeloid cells 2, Trem2c, Trem2b, Trem2a, TREM-2
Anti-TREM-2 Antibody-HRP (4H451) is a HRP-conjugated Mouse antibody targeting TREM-2. Anti-TREM-2 Antibody-HRP (4H451) can be used in ELISA.
Anti-TREM-2 Antibody-HRP (4H451)
Anti-TREM-2 Antibody-HRP (4H451)
😃Good
Catalog No. TMAY-01617HAlias triggering receptor expressed on myeloid cells 2, Trem2c, Trem2b, Trem2a, TREM-2
Anti-TREM-2 Antibody-HRP (4H451) is a HRP-conjugated Mouse antibody targeting TREM-2. Anti-TREM-2 Antibody-HRP (4H451) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μg | $292 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA Reactivity: Human |
| Alias | triggering receptor expressed on myeloid cells 2, Trem2c, Trem2b, Trem2a, TREM-2 |
| Ig Type | Mouse IgG1 |
| Clone | 4H451 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 0.1-1 μg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TREM-2 / TREM2 (rh TREM-2 / TREM2; TMPY-01148; NP_061838.1; Met1-Ser174). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary. |
| Conjucates | HRP |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Protein: Human TREM-2 / TREM2 Protein (TMPY-01148) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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