Shopping Cart
Remove All
Your shopping cart is currently empty
PROTAC Akt3 Degrader-1
Catalog No. T216025 Copy Product Info
🥰Excellent
PROTACAkt3Degrader-1 is an effective and selective PROTAC degrader targeting Akt3. It exhibits relatively weak antiproliferative activity across 36 cell lines. PROTACAkt3Degrader-1 is applicable in research on triple-negative breast cancer and melanoma.
PROTAC Akt3 Degrader-1
Copy Product Info🥰Excellent
Catalog No. T216025
PROTACAkt3Degrader-1 is an effective and selective PROTAC degrader targeting Akt3. It exhibits relatively weak antiproliferative activity across 36 cell lines. PROTACAkt3Degrader-1 is applicable in research on triple-negative breast cancer and melanoma.
PROTAC Akt3 Degrader-1
Cas No. 3048204-93-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Quotation
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
Resource Download
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PROTACAkt3Degrader-1 is an effective and selective PROTAC degrader targeting Akt3. It exhibits relatively weak antiproliferative activity across 36 cell lines. PROTACAkt3Degrader-1 is applicable in research on triple-negative breast cancer and melanoma. |
| In vitro | PROTAC Akt3 Degrader-1 (Compound 12) efficiently induces the degradation of Akt3 in MDA-MB-468 cells with a DC50 of 7.5 nM, while it has no significant impact on Akt1 and Akt2 degradation (DC50 > 5000 nM). At a concentration of 0.2 μM for 24 hours, this compound acts as a highly specific degrader of Akt3, significantly reducing the expression of Akt3 and TMEM120B proteins in MDA-MB-468 cells with minimal off-target effects. When tested in MDA-MB-231 cells, it induces Akt3 degradation with a DC50 of 7.0 nM and a DC50 of 54.3 nM in A-375 cells. The compound shows IC50 values > 30 μM in MDA-MB-468 cells and 13.5 μM in MDA-MB-231 cells. |
| Molecular Weight | 851.45 |
| Formula | C46H55ClN8O6 |
| Cas No. | 3048204-93-6 |
| Smiles | C([C@H](CNC(CCCCCCCCCCC1=C2C(C(=O)N(C2)C3C(=O)NC(=O)CC3)=CC=C1)=O)C4=CC=C(Cl)C=C4)(=O)N5[C@]6([C@@](N(CC5)C7=C8C(NC=N7)=NC(=O)C[C@H]8C)(C6)[H])[H] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
Citations
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy PROTAC Akt3 Degrader-1 | purchase PROTAC Akt3 Degrader-1 | PROTAC Akt3 Degrader-1 cost | order PROTAC Akt3 Degrader-1 | PROTAC Akt3 Degrader-1 in vitro | PROTAC Akt3 Degrader-1 formula | PROTAC Akt3 Degrader-1 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.