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Lexithromycin

Name: Lexithromycin
Brand: TargetMol
SKU: T15747
Rating: 4.5 (1 reviews)

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Catalog No. T15747Cas No. 53066-26-5

Alias Wy 48314, Erythromycin A 9-methoxime

Lexithromycin is an erythromycin A derivative. It has antibacterial activity.

Lexithromycin

😃Good

Catalog No. T15747Alias Wy 48314, Erythromycin A 9-methoximeCas No. 53066-26-5

Lexithromycin is an erythromycin A derivative. It has antibacterial activity.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$428	35 days	35 days
25 mg	$1,900	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Lexithromycin is an erythromycin A derivative. It has antibacterial activity.
In vitro	Lexithromycin shows a minimal inhibitory concentration of 0.06 μg/mL against S. pyogenes CN10A and Streptococcus sp. The .minimal inhibitory concentration of 0.25 μg/mL against Staphylococcus aureus Oxford, 0.5 μg/mL against S. aureus Russell and S. aureus T2, 4 μg/mL against S. pyogenes CN10A and Haemophilus influenzae Wy 21[1].
Synonyms	Wy 48314, Erythromycin A 9-methoxime

Chemical Properties

Molecular Weight	762.97
Formula	C₃₈H₇₀N₂O₁₃
Cas No.	53066-26-5
Smiles	[H][C@@]1(C[C@@](C)(OC)[C@@H](O)[C@H](C)O1)O[C@@]1([H])[C@H](C)[C@@H](O[C@]2([H])O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)\C(=N/OC)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C
Relative Density.	1.26g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (65.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3107 mL	6.5533 mL	13.1067 mL	65.5334 mL
5 mM	0.2621 mL	1.3107 mL	2.6213 mL	13.1067 mL
10 mM	0.1311 mL	0.6553 mL	1.3107 mL	6.5533 mL
20 mM	0.0655 mL	0.3277 mL	0.6553 mL	3.2767 mL
50 mM	0.0262 mL	0.1311 mL	0.2621 mL	1.3107 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc