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Anti-CDC2 Monoclonal Antibody (4L423)
(Synonyms: P34CDC2, MGC111195, DKFZp686L20222, CDK1, CDC28A, CDC2) Copy Product Info
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Synonyms: P34CDC2, MGC111195, DKFZp686L20222, CDK1, CDC28A, CDC2
Catalog No. TMAT-0464 Copy Product Info
🥰Excellent
Anti-CDC2 Monoclonal Antibody (4L423) is a Mouse antibody targeting CDC2. Anti-CDC2 Monoclonal Antibody (4L423) can be used in WB,IHC.
Anti-CDC2 Monoclonal Antibody
(4L423)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 20 µL | Inquiry | 7-10 days | 7-10 days | |
| 50 µL | Inquiry | 7-10 days | 7-10 days | |
| 100 µL | Inquiry | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-CDC2 Monoclonal Antibody (4L423) is a Mouse antibody targeting CDC2. Anti-CDC2 Monoclonal Antibody (4L423) can be used in WB,IHC. |
| Synonyms | P34CDC2, MGC111195, DKFZp686L20222, CDK1, CDC28A, CDC2 |
| Ig Type | IgG1 |
| Clone | 4L423 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | Ascitic fluid containing 0.03% sodium azide |
| Concentration | 1 mg/ml |
| Research Background | The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of CDC2 expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | CDK1 |
| Gene ID | |
| Protein Name | Cyclin-dependent kinase 1 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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