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TRIM24/BRPF1-IN-2

🥰Excellent
Catalog No. T74271Cas No. 3033288-68-2

TRIM24/BRPF1-IN-2 is a selective dual TRIM24/BRPF1 inhibitor with anticancer activity that inhibits proliferation, gene and protein expression, and colony formation of prostate cancer cells in a dose-dependent manner.

TRIM24/BRPF1-IN-2

TRIM24/BRPF1-IN-2

🥰Excellent
Purity: 99.13%
Catalog No. T74271Cas No. 3033288-68-2
TRIM24/BRPF1-IN-2 is a selective dual TRIM24/BRPF1 inhibitor with anticancer activity that inhibits proliferation, gene and protein expression, and colony formation of prostate cancer cells in a dose-dependent manner.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$335In StockIn Stock
5 mg$970In StockIn Stock
50 mgInquiryIn StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.13%
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Product Introduction

Bioactivity
Description
TRIM24/BRPF1-IN-2 is a selective dual TRIM24/BRPF1 inhibitor with anticancer activity that inhibits proliferation, gene and protein expression, and colony formation of prostate cancer cells in a dose-dependent manner.
Targets&IC50
22Rv1 cells:0.82 μM, BRPF1:1.16 μM, LNCaP cells:1.07 μM, C4-2B cells:0.78 μM
In vitro
TRIM24/BRPF1-IN-2 significantly inhibited the growth of prostate cell lines (C4-2B, LNCaP, and 22Rv1) after treatment at concentrations of 0-10 μM for 48 h. The IC50 values were 0.78 μM, 1.07 μM, and 0.82 μM, respectively.TRIM24/BRPF1-IN-2 was also able to inhibit prostate cancer cells' gene and protein expression. In addition, TRIM24/BRPF1-IN-2 showed good Caco-2 permeability. [1]
In vivo
TRIM24/BRPF1-IN-2 administered once daily by intraperitoneal injection for 21 consecutive days at a dose of 50 mg/kg significantly inhibited tumor growth (TGI = 53%) and no significant toxicity was observed. [1]
Chemical Properties
Molecular Weight386.47
FormulaC20H22N2O4S
Cas No.3033288-68-2
SmilesO=C(N1C2=CC=C(C=C2CC1)NS(=O)(=O)C3=CC(=CC=C3OC)C4CC4)C
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

EpigeneticReaderDomainEpigenetic Reader DomainBRPF1
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