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Cis-22a

Name: Cis-22a
Brand: TargetMol
SKU: T41233
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T41233Cas No. 1819366-84-1

Cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells.

Cis-22a

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Purity: 99.99%

Catalog No. T41233Cas No. 1819366-84-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$129	In Stock	In Stock
5 mg	$315	In Stock	In Stock
10 mg	$585	In Stock	In Stock
25 mg	$937	In Stock	In Stock
50 mg	$1,270	In Stock	In Stock
100 mg	$1,720	In Stock	In Stock
500 mg	$3,430	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

Appearance:Solid

Color:White

Resource Download

COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	Cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells.
Targets&IC50	TRPV6:0.32 μM

Chemical Properties

Molecular Weight	449.51
Formula	C₂₄H₃₀F₃N₃O₂
Cas No.	1819366-84-1
Smiles	C(C(O)=O)(F)(F)F.CC=1C=C([C@H]2CC[C@H](CC2)N3CCN(CC3)C=4C=CC=NC4)C=CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (200.22 mM), Sonication is recommended.

H2O: 90 mg/mL (200.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.2246 mL	11.1232 mL	22.2464 mL	111.2322 mL
5 mM	0.4449 mL	2.2246 mL	4.4493 mL	22.2464 mL
10 mM	0.2225 mL	1.1123 mL	2.2246 mL	11.1232 mL
20 mM	0.1112 mL	0.5562 mL	1.1123 mL	5.5616 mL
50 mM	0.0445 mL	0.2225 mL	0.4449 mL	2.2246 mL
100 mM	0.0222 mL	0.1112 mL	0.2225 mL	1.1123 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc