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Cis-22a

Name: Cis-22a
Brand: TargetMol
SKU: T41233
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T41233Cas No. 1819366-84-1

Cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells.

Cis-22a

🥰Excellent

Purity: 99.07%

Catalog No. T41233Cas No. 1819366-84-1

Pack Size	Price	Availability
1 mg	$129	In Stock
5 mg	$315	In Stock
10 mg	$585	In Stock
25 mg	$937	In Stock
50 mg	$1,270	In Stock
100 mg	$1,720	In Stock
500 mg	$3,430	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.07%

Resource Download

COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	Cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells.
Targets&IC50	TRPV6:0.32 μM

Chemical Properties

Molecular Weight	449.51
Formula	C₂₄H₃₀F₃N₃O₂
Cas No.	1819366-84-1
Smiles	C(C(O)=O)(F)(F)F.CC=1C=C([C@H]2CC[C@H](CC2)N3CCN(CC3)C=4C=CC=NC4)C=CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (200.22 mM), Sonication is recommended.

H2O: 90 mg/mL (200.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.2246 mL	11.1232 mL	22.2464 mL	111.2322 mL
5 mM	0.4449 mL	2.2246 mL	4.4493 mL	22.2464 mL
10 mM	0.2225 mL	1.1123 mL	2.2246 mL	11.1232 mL
20 mM	0.1112 mL	0.5562 mL	1.1123 mL	5.5616 mL
50 mM	0.0445 mL	0.2225 mL	0.4449 mL	2.2246 mL
100 mM	0.0222 mL	0.1112 mL	0.2225 mL	1.1123 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc