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Anti-Aminoacylase 1 Antibody (1K198)

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Catalog No. TMAY-00964
Alias HEL-S-5, aminoacylase 1, ACY1D, ACY-1

Anti-Aminoacylase 1 Antibody (1K198) is a Rabbit antibody targeting Aminoacylase 1. Anti-Aminoacylase 1 Antibody (1K198) can be used in IHC-P.

Anti-Aminoacylase 1 Antibody (1K198)

Anti-Aminoacylase 1 Antibody (1K198)

😃Good
Catalog No. TMAY-00964Alias HEL-S-5, aminoacylase 1, ACY1D, ACY-1
Anti-Aminoacylase 1 Antibody (1K198) is a Rabbit antibody targeting Aminoacylase 1. Anti-Aminoacylase 1 Antibody (1K198) can be used in IHC-P.
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100 μL$269 7-10 days
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Product Introduction

Bioactivity
Description
Anti-Aminoacylase 1 Antibody (1K198) is a Rabbit antibody targeting Aminoacylase 1. Anti-Aminoacylase 1 Antibody (1K198) can be used in IHC-P.
AliasHEL-S-5, aminoacylase 1, ACY1D, ACY-1
Ig Type
Monoclonal Rabbit IgG
Clone
1K198
Reactivity
Human
Verified Activity
Immunochemical staining of human ACY1 in human kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to nephric tubule.
Application
IHC-P
Recommended Dose
IHC-P: 1:100-1:500
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human ACY1 / Aminoacylase-1 (rh ACY1 / Aminoacylase-1; TMPY-01058; NP_000657.1; Met1-Ser408).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundAminoacylase 1 (ACY1), a metalloenzyme that removes amide-linked ACY1 groups from amino acids and may play a role in regulating responses to oxidative stress. Both the C-terminal fragment found in the two-hybrid screen and full-length ACY1 co-immunoprecipitate with SphK1. Though both C-terminal and full-length proteins slightly reduce SphK1 activity measured in vitro, the C-terminal fragment inhibits while full-length ACY1 potentiates the effects of SphK1 on proliferation and apoptosis. It suggested that ACY1 physically interacts with SphK1 and may influence its physiological functions. As a homodimeric zinc-binding enzyme, Aminoacylase 1 catalyzes the hydrolysis of N alpha-acylated amino acids. Deficiency of Aminoacylase 1 due to mutations in the Aminoacylase 1 (ACY1) gene follows an autosomal-recessive trait of inheritance and is characterized by accumulation of N-acetyl amino acids in the urine.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human ACY1 / Aminoacylase-1 protein (TMPY-01058)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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