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NU6300

Name: NU6300
Brand: TargetMol
SKU: T16360
Price: 999 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16360Cas No. 2070015-09-5

Alias NU 6300

NU6300 is an inhibitor of the first covalent ATP-competitive CDK2.

NU6300

🥰Excellent

Purity: 96.08%

Catalog No. T16360Alias NU 6300Cas No. 2070015-09-5

NU6300 is an inhibitor of the first covalent ATP-competitive CDK2.

Pack Size	Price	Availability	Quantity
5 mg	$999	In Stock

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Batch Information

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Purity:96.08%

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COA

Product Introduction

Bioactivity

Description	NU6300 is an inhibitor of the first covalent ATP-competitive CDK2.
Targets&IC50	CDK2:0.16 μM
In vitro	NU6300 blocks the inhibitor binding site. The effect was time-dependent and relatively slow, with less than 50% reduction of the apparent binding capacity in 20 hr. NU6300 is a covalent CDK2 inhibitor that illustrates the potential of using vinyl sulfones to mediate irreversible inhibition.
Synonyms	NU 6300

Chemical Properties

Molecular Weight	413.49
Formula	C₂₀H₂₃N₅O₃S
Cas No.	2070015-09-5
Smiles	C=CS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3nc[nH]c3n2)cc1
Relative Density.	1.344 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (193.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4184 mL	12.0922 mL	24.1844 mL	120.9219 mL
5 mM	0.4837 mL	2.4184 mL	4.8369 mL	24.1844 mL
10 mM	0.2418 mL	1.2092 mL	2.4184 mL	12.0922 mL
20 mM	0.1209 mL	0.6046 mL	1.2092 mL	6.0461 mL
50 mM	0.0484 mL	0.2418 mL	0.4837 mL	2.4184 mL
100 mM	0.0242 mL	0.1209 mL	0.2418 mL	1.2092 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc