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NU6300

Name: NU6300
Brand: TargetMol
SKU: T16360
Price: 999 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16360Cas No. 2070015-09-5

Alias NU 6300

NU6300 is an inhibitor of the first covalent ATP-competitive CDK2.

NU6300

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Purity: 96.08%

Catalog No. T16360Alias NU 6300Cas No. 2070015-09-5

NU6300 is an inhibitor of the first covalent ATP-competitive CDK2.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$999	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:96.08%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	NU6300 is an inhibitor of the first covalent ATP-competitive CDK2.
Targets&IC50	CDK2:0.16 μM
In vitro	NU6300 blocks the inhibitor binding site. The effect was time-dependent and relatively slow, with less than 50% reduction of the apparent binding capacity in 20 hr. NU6300 is a covalent CDK2 inhibitor that illustrates the potential of using vinyl sulfones to mediate irreversible inhibition.
Synonyms	NU 6300

Chemical Properties

Molecular Weight	413.49
Formula	C₂₀H₂₃N₅O₃S
Cas No.	2070015-09-5
Smiles	C=CS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3nc[nH]c3n2)cc1
Relative Density.	1.344 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (193.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4184 mL	12.0922 mL	24.1844 mL	120.9219 mL
5 mM	0.4837 mL	2.4184 mL	4.8369 mL	24.1844 mL
10 mM	0.2418 mL	1.2092 mL	2.4184 mL	12.0922 mL
20 mM	0.1209 mL	0.6046 mL	1.2092 mL	6.0461 mL
50 mM	0.0484 mL	0.2418 mL	0.4837 mL	2.4184 mL
100 mM	0.0242 mL	0.1209 mL	0.2418 mL	1.2092 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc