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Anti-Phospho-MCL1 (Ser159) Polyclonal Antibody
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Catalog No. TMAB-10957
Anti-Phospho-MCL1 (Ser159) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MCL1 (Ser159). Anti-Phospho-MCL1 (Ser159) Polyclonal Antibody can be used in IHC-P,IHC-Fr,ICC/IF,IF.
Anti-Phospho-MCL1 (Ser159) Polyclonal Antibody
Anti-Phospho-MCL1 (Ser159) Polyclonal Antibody
😃Good
Catalog No. TMAB-10957
Anti-Phospho-MCL1 (Ser159) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MCL1 (Ser159). Anti-Phospho-MCL1 (Ser159) Polyclonal Antibody can be used in IHC-P,IHC-Fr,ICC/IF,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-MCL1 (Ser159) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MCL1 (Ser159). Anti-Phospho-MCL1 (Ser159) Polyclonal Antibody can be used in IHC-P,IHC-Fr,ICC/IF,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat,Pig,Horse,Rabbit) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Single-pass membrane protein (Potential). Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it. Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML1. |
| Immunogen | KLH conjugated synthesised phosphopeptide: human Mcl 1 around the phosphorylation site of Ser159. |
| Antigen Species | Human |
| Gene Name | MCL1 |
| Gene ID | |
| Protein Name | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| Uniprot ID | |
| Function | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. |
| Molecular Weight | Theoretical: 37 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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