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NBI-27914

Name: NBI-27914
Brand: TargetMol
SKU: T62444
Rating: 4.5 (1 reviews)

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Catalog No. T62444Cas No. 184241-44-9

Alias NBI27914

NBI-27914 is a selective and non-peptide CRFR1 (corticotropin-releasing factor receptor 1) antagonist with analgesic effects, capable of blocking CRF-induced anxiety.

NBI-27914

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Purity: 99.64%

Catalog No. T62444Alias NBI27914Cas No. 184241-44-9

NBI-27914 is a selective and non-peptide CRFR1 (corticotropin-releasing factor receptor 1) antagonist with analgesic effects, capable of blocking CRF-induced anxiety.

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Purity:99.64%

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Product Introduction

Bioactivity

Description	NBI-27914 is a selective and non-peptide CRFR1 (corticotropin-releasing factor receptor 1) antagonist with analgesic effects, capable of blocking CRF-induced anxiety.
Synonyms	NBI27914

Chemical Properties

Molecular Weight	434.19
Formula	C₁₈H₂₀Cl₄N₄
Cas No.	184241-44-9
Smiles	ClC=1C=C(Cl)C(NC=2N=C(N=C(C2Cl)N(CCC)CC3CC3)C)=C(Cl)C1

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (184.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3031 mL	11.5157 mL	23.0314 mL	115.1570 mL
5 mM	0.4606 mL	2.3031 mL	4.6063 mL	23.0314 mL
10 mM	0.2303 mL	1.1516 mL	2.3031 mL	11.5157 mL
20 mM	0.1152 mL	0.5758 mL	1.1516 mL	5.7578 mL
50 mM	0.0461 mL	0.2303 mL	0.4606 mL	2.3031 mL
100 mM	0.0230 mL	0.1152 mL	0.2303 mL	1.1516 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc