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NBI-27914

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Catalog No. T62444Cas No. 184241-44-9
Alias NBI27914

NBI-27914 is a selective and non-peptide CRFR1 (corticotropin-releasing factor receptor 1) antagonist with analgesic effects, capable of blocking CRF-induced anxiety.

NBI-27914

NBI-27914

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Purity: 99.64%
Catalog No. T62444Alias NBI27914Cas No. 184241-44-9
NBI-27914 is a selective and non-peptide CRFR1 (corticotropin-releasing factor receptor 1) antagonist with analgesic effects, capable of blocking CRF-induced anxiety.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$39-In Stock
5 mg$89-In Stock
10 mg$147-In Stock
25 mg$313-In Stock
50 mgPreferential-In Stock
1 mL x 10 mM (in DMSO)$98-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.64%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
NBI-27914 is a selective and non-peptide CRFR1 (corticotropin-releasing factor receptor 1) antagonist with analgesic effects, capable of blocking CRF-induced anxiety.
SynonymsNBI27914
Chemical Properties
Molecular Weight434.19
FormulaC18H20Cl4N4
Cas No.184241-44-9
SmilesClC=1C=C(Cl)C(NC=2N=C(N=C(C2Cl)N(CCC)CC3CC3)C)=C(Cl)C1
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (184.25 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3031 mL11.5157 mL23.0314 mL115.1570 mL
5 mM0.4606 mL2.3031 mL4.6063 mL23.0314 mL
10 mM0.2303 mL1.1516 mL2.3031 mL11.5157 mL
20 mM0.1152 mL0.5758 mL1.1516 mL5.7578 mL
50 mM0.0461 mL0.2303 mL0.4606 mL2.3031 mL
100 mM0.0230 mL0.1152 mL0.2303 mL1.1516 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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