BP Fluor 488 Tetrazine is a bright green fluorescent probe designed for detecting TCO-labeled biopolymers. It demonstrates exceptionally fast cycloaddition kinetics (up to 30,000 M-1 s-1) with trans-cyclooctene (TCO) as the dienophile, marking the fastest kinetics in any bioorthogonal reaction to date. This probe is highly valuable for applications requiring rapid reaction kinetics, such as in vivo cancer imaging or pre-targeted cell labeling studies.