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Centrinone-B

Name: Centrinone-B
Brand: TargetMol
SKU: T14926
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14926Cas No. 1798871-31-4

Alias LCR-323, LCR323, LCR 323

Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor with a Ki of 0.59 nM.

Centrinone-B

🥰Excellent

Purity: 98.71%

Catalog No. T14926Alias LCR-323, LCR323, LCR 323Cas No. 1798871-31-4

Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor with a Ki of 0.59 nM.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$199	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.71%

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COA LCMS

Product Introduction

Bioactivity

Description	Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor with a Ki of 0.59 nM.
Targets&IC50	Aurora B:5597.14 nM (Ki), Aurora A:1239 nM (Ki), PLK4:0.59 nM (Ki), PLK4 (G95L):497.53 nM (Ki)
In vitro	Centrinone-B (LCR-323) is a highly potent and selective PLK4 inhibitor that can reduce centrosomes without affecting Aurora A/B, and it induces apoptosis in most melanoma cell lines[2].
Synonyms	LCR-323, LCR323, LCR 323

Chemical Properties

Molecular Weight	631.67
Formula	C₂₇H₂₇F₂N₇O₅S₂
Cas No.	1798871-31-4
Smiles	COc1c(Nc2cc(C)[nH]n2)nc(Sc2ccc(cc2F)S(=O)(=O)Cc2cccc(c2F)[N+]([O-])=O)nc1N1CCCCC1
Relative Density.	1.54 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (31.66 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (3.17 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5831 mL	7.9155 mL	15.8311 mL	79.1553 mL
5 mM	0.3166 mL	1.5831 mL	3.1662 mL	15.8311 mL
10 mM	0.1583 mL	0.7916 mL	1.5831 mL	7.9155 mL
20 mM	0.0792 mL	0.3958 mL	0.7916 mL	3.9578 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc