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BpV(phen) trihydrate

Name: BpV(phen) trihydrate
Brand: TargetMol
SKU: T41339
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T41339Cas No. 171202-16-7

Alias Bisperoxovanadium(phen) trihydrate

BpV(phen) trihydrate is an insulin mimic and an effective PTP and PTEN inhibitor, with an IC50 of 38/343/920 nM for PTEN/PTP-β/PTP-1B, and has inhibitory activity against leishmania, can induce apoptosis and promote the secretion of pro-inflammatory factors, activate the Th1 pathway, and has anti-angiogenic and anti-tumor activity.

BpV(phen) trihydrate

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Catalog No. T41339Alias Bisperoxovanadium(phen) trihydrateCas No. 171202-16-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	BpV(phen) trihydrate is an insulin mimic and an effective PTP and PTEN inhibitor, with an IC50 of 38/343/920 nM for PTEN/PTP-β/PTP-1B, and has inhibitory activity against leishmania, can induce apoptosis and promote the secretion of pro-inflammatory factors, activate the Th1 pathway, and has anti-angiogenic and anti-tumor activity.
Targets&IC50	PTP-1B:920 nM, PTEN:38 nM, PTPβ:343 nM
In vitro	Bpv(phen) (5 mg/kg; intraperitoneal injection; daily; for 38 days; male BALB/c nude (nu/nu) athymic mice) treatment causes a significant reduction in average tumor volume[1].
In vivo	Bpv(phen) (5 μM; 24.5 hours; H9c2 cells) reduces survival rates and promotes apoptosis in hypoxia/reperfusion-injured H9c2 cells, facilitating the accumulation of cytochrome C in the cytoplasm [1]. Bpv(phen), an insulin-like substance, exerts its effects through hyperphosphorylation and activation of insulin receptor tyrosine kinase [4].
Synonyms	Bisperoxovanadium(phen) trihydrate

Chemical Properties

Molecular Weight	404.29
Formula	C₁₂H₁₄KN₂O₈V
Cas No.	171202-16-7
Smiles	O=[V+3]123([O-][O-]2)([N]4=C5C6=[N]3C=CC=C6C=CC5=CC=C4)[O-][O-]1.[K+].O.O.O

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (197.88 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.4735 mL	12.3674 mL	24.7347 mL	123.6736 mL
5 mM	0.4947 mL	2.4735 mL	4.9469 mL	24.7347 mL
10 mM	0.2473 mL	1.2367 mL	2.4735 mL	12.3674 mL
20 mM	0.1237 mL	0.6184 mL	1.2367 mL	6.1837 mL
50 mM	0.0495 mL	0.2473 mL	0.4947 mL	2.4735 mL
100 mM	0.0247 mL	0.1237 mL	0.2473 mL	1.2367 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc