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BpV(phen) trihydrate

Name: BpV(phen) trihydrate
Brand: TargetMol
SKU: T41339
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T41339Cas No. 171202-16-7

Alias Bisperoxovanadium(phen) trihydrate

BpV(phen) trihydrate is an insulin mimic and an effective PTP and PTEN inhibitor, with an IC50 of 38/343/920 nM for PTEN/PTP-β/PTP-1B, and has inhibitory activity against leishmania, can induce apoptosis and promote the secretion of pro-inflammatory factors, activate the Th1 pathway, and has anti-angiogenic and anti-tumor activity.

BpV(phen) trihydrate

😃Good

Catalog No. T41339Alias Bisperoxovanadium(phen) trihydrateCas No. 171202-16-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$29	-	In Stock

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Product Introduction

Bioactivity

Description	BpV(phen) trihydrate is an insulin mimic and an effective PTP and PTEN inhibitor, with an IC50 of 38/343/920 nM for PTEN/PTP-β/PTP-1B, and has inhibitory activity against leishmania, can induce apoptosis and promote the secretion of pro-inflammatory factors, activate the Th1 pathway, and has anti-angiogenic and anti-tumor activity.
Targets&IC50	PTPβ:343 nM, PTP-1B:920 nM, PTEN:38 nM
In vitro	Bpv(phen) (5 mg/kg; intraperitoneal injection; daily; for 38 days; male BALB/c nude (nu/nu) athymic mice) treatment causes a significant reduction in average tumor volume[1].
In vivo	Bpv(phen) (5 μM; 24.5 hours; H9c2 cells) reduces survival rates and promotes apoptosis in hypoxia/reperfusion-injured H9c2 cells, facilitating the accumulation of cytochrome C in the cytoplasm [1]. Bpv(phen), an insulin-like substance, exerts its effects through hyperphosphorylation and activation of insulin receptor tyrosine kinase [4].
Synonyms	Bisperoxovanadium(phen) trihydrate

Chemical Properties

Molecular Weight	404.29
Formula	C₁₂H₁₄KN₂O₈V
Cas No.	171202-16-7
Smiles	O=[V+3]123([O-][O-]2)([N]4=C5C6=[N]3C=CC=C6C=CC5=CC=C4)[O-][O-]1.[K+].O.O.O
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (197.88 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.4735 mL	12.3674 mL	24.7347 mL	123.6736 mL
5 mM	0.4947 mL	2.4735 mL	4.9469 mL	24.7347 mL
10 mM	0.2473 mL	1.2367 mL	2.4735 mL	12.3674 mL
20 mM	0.1237 mL	0.6184 mL	1.2367 mL	6.1837 mL
50 mM	0.0495 mL	0.2473 mL	0.4947 mL	2.4735 mL
100 mM	0.0247 mL	0.1237 mL	0.2473 mL	1.2367 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc