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Imidazoleacetic acid

Name: Imidazoleacetic acid
Brand: TargetMol
SKU: T13735
Rating: 4.5 (1 reviews)

(Synonyms: Imidazolyl-4-acetic acid) Copy Product Info

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Synonyms: Imidazolyl-4-acetic acid

Catalog No. T13735 Copy Product Info

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Imidazoleacetic acid (Imidazolyl-4-acetic acid) is a blood-brain barrier-permeable full agonist of the GABAA receptor. Imidazoleacetic acid is generated through histamine oxidation in the mouse brain and exerts multiple neurochemical and behavioral effects. Imidazoleacetic acid induces centrally mediated responses including analgesia, sedation, hypnosis, and reductions in blood pressure, body temperature, isolation-induced aggression, and motor activity. Imidazoleacetic acid is valuable for neuropharmacology and neurotransmitter signaling investigations involving histaminergic and GABAergic pathways.

Cas No. 645-65-8

Pack Size	Price	USA Stock	Global Stock
25 mg	$42	7-10 days	7-10 days
50 mg	$77	7-10 days	7-10 days
100 mg	$112	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$29	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Imidazoleacetic acid (Imidazolyl-4-acetic acid) is a blood-brain barrier-permeable full agonist of the GABAA receptor. Imidazoleacetic acid is generated through histamine oxidation in the mouse brain and exerts multiple neurochemical and behavioral effects. Imidazoleacetic acid induces centrally mediated responses including analgesia, sedation, hypnosis, and reductions in blood pressure, body temperature, isolation-induced aggression, and motor activity. Imidazoleacetic acid is valuable for neuropharmacology and neurotransmitter signaling investigations involving histaminergic and GABAergic pathways.
In vitro	Imidazoleacetic acid has agonist activity at human GABAC rho 1 receptor expressed in HEK293 cells by FMP assay with EC50 value of 13 μM[1]. Imidazoleacetic acid has agonist activity at GABA alpha-1-beta-2-gamma-2 receptor expressed in HEK293 cells by Whole-cell patch-clamp technique with EC50 value of 138 μM[1]. Imidazoleacetic acid has agonist activity at rat GABA alpha-1-T129S-beta-2-gamma-2 receptor mutant expressed in HEK293 cells by Whole-cell patch-clamp technique with EC50 value of 20 μM[1]. Imidazoleacetic acid has agonist activity at rat GABA alpha-1-T129S-beta-2-gamma-2 receptor mutant expressed in HEK293 cells by Whole-cell patch-clamp technique with EC50 value of 5.5 μM[1]. Imidazoleacetic acid has agonist activity on human Gamma-aminobutyric acid A receptor alpha-3-beta-3-gamma-2 expressed in Xenopus oocytes with EC50 value of 300 μM[2]. Imidazoleacetic acid has effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytes with EC50 value of 310 μM[2]. Imidazoleacetic acid has effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytes with EC50 value of 420 μM[2]. Imidazoleacetic acid has agonist activity on human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 expressed in Xenopus oocytes with EC50 value of 600 μM[2].
Synonyms	Imidazolyl-4-acetic acid

Chemical Properties

Molecular Weight	126.11
Formula	C₅H₆N₂O₂
Cas No.	645-65-8
Smiles	O=C(O)CC1=CN=CN1
Relative Density.	1.426 g/cm3

Storage & Solubility Information

Storage

Keep away from moisture,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 6.66 mg/mL (52.81 mM), Sonication is recommended.

H2O: Soluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.9296 mL	39.6479 mL	79.2959 mL	396.4793 mL
5 mM	1.5859 mL	7.9296 mL	15.8592 mL	79.2959 mL
10 mM	0.7930 mL	3.9648 mL	7.9296 mL	39.6479 mL
20 mM	0.3965 mL	1.9824 mL	3.9648 mL	19.8240 mL
50 mM	0.1586 mL	0.7930 mL	1.5859 mL	7.9296 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Imidazoleacetic acidHuman Endogenous Metabolite

Related Tags: Imidazoleacetic acid chemical structure | Imidazoleacetic acid in vitro | Imidazoleacetic acid formula | Imidazoleacetic acid molecular weight