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Anti-TrkA Antibody (2F839)
😃Good
Catalog No. TMAH-00832
Alias TrkA-I, TrkAI, TrkA I, Trk-A, TRKA, TRK, NTRK1, MTC
Anti-TrkA Antibody (2F839) is an antibody targeting TrkA. Anti-TrkA Antibody (2F839) can be used in ELISA, WB.
Anti-TrkA Antibody (2F839)
Anti-TrkA Antibody (2F839)
😃Good
Catalog No. TMAH-00832Alias TrkA-I, TrkAI, TrkA I, Trk-A, TRKA, TRK, NTRK1, MTC
Anti-TrkA Antibody (2F839) is an antibody targeting TrkA. Anti-TrkA Antibody (2F839) can be used in ELISA, WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $349 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, WB Reactivity: Human, Mouse, Rat |
| Alias | TrkA-I, TrkAI, TrkA I, Trk-A, TRKA, TRK, NTRK1, MTC |
| Ig Type | Rabbit IgG |
| Clone | 2F839 |
| Reactivity | Human, Mouse, Rat |
| Verified Activity | Western Blot -Positive WB detected in: Rat Brain whole cell lysate, Mouse Brain whole cell lysate -All lanes: TrkA Antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 88, 87, 84, 78 kDa -Observed band size: 145 kDa |
| Application | ELISA, WB |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Recycling endosome membrane; Single-pass type I membrane protein. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Resistant to NGF, it constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human TrkA |
| Antigen Species | Human |
| Gene ID | 4914 |
| Uniprot ID | |
| Biology Area | Other |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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