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Avitinib maleate

Name: Avitinib maleate
Brand: TargetMol
SKU: T3721
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3721Cas No. 1557268-88-8

Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.

Avitinib maleate

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Purity: 99.74%

Catalog No. T3721Cas No. 1557268-88-8

Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$67	In Stock	In Stock
10 mg	$117	In Stock	In Stock
25 mg	$219	In Stock	In Stock
50 mg	$372	In Stock	In Stock
100 mg	$597	-	In Stock
1 mL x 10 mM (in DMSO)	$90	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.74%

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.
Targets&IC50	EGFR (WT):7.68 nM, EGFR L858R/T790M:0.18 nM, EGFR:7.68 nM

Chemical Properties

Molecular Weight	603.61
Formula	C₃₀H₃₀FN₇O₆
Cas No.	1557268-88-8
Smiles	OC(=O)\C=C/C(O)=O.CN1CCN(CC1)c1ccc(Nc2nc(Oc3cccc(NC(=O)C=C)c3)c3cc[nH]c3n2)cc1F
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 300 mg/mL (497.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (8.28 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6567 mL	8.2835 mL	16.5670 mL	82.8349 mL
5 mM	0.3313 mL	1.6567 mL	3.3134 mL	16.5670 mL
10 mM	0.1657 mL	0.8283 mL	1.6567 mL	8.2835 mL
20 mM	0.0828 mL	0.4142 mL	0.8283 mL	4.1417 mL
50 mM	0.0331 mL	0.1657 mL	0.3313 mL	1.6567 mL
100 mM	0.0166 mL	0.0828 mL	0.1657 mL	0.8283 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc