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MAdCAM-1 Protein, Human, Recombinant (His)

MAdCAM-1 Protein, Human, Recombinant (His)
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MAdCAM-1 Protein, Human, Recombinant (His)

Catalog No. TMPJ-01152
MAdCAM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-65 KDa and the accession number is Q4PKD0.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
10 μg$1077-10 days
50 μg$3247-10 days
500 μg$1,9507-10 days
1 mg$2,9407-10 days
Bulk & Custom
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Biological Description

Description
MAdCAM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-65 KDa and the accession number is Q4PKD0.
Species
Human
Expression System
HEK293 Cells
TagC-6xHis
Accession NumberQ4PKD0
Synonyms
MAdCAM1,hMAdCAM-1,MACAM1,mucosal addressin cell adhesion molecule 1,MAdCAM-1
Amino Acid
Gln19-Gln333
Construction
Gln19-Gln333
Protein Purity
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight55-65 KDa (reducing condition)
Endotoxin< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution
Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is an approximately 60 kDa type 1 transmembrane glycoprotein. It is an endothelial cell adhesion molecule that belongs to the immunoglobulin (Ig) superfamily of proteins. The Ig domains of MAdCAM-1 are critical to alpha (4) beta (7) binding, and the mucin domain has activity in L Selectin binding. MAdCAM-1 expression is up-regulated by TNF-alpha and IL 1 beta. Mucosal addressin cell adhesion molecule (MAdCAM-1) plays a pivotal role in T-lymphocyte homing to the gut. MAdCAM 1 expression is also dramatically increased in chronic inflammatory and disease states, including inflammatory bowel disease (Crohn’s disease and ulcerative colitis), sclerosing cholangitis, and diabetes, and may play an important role in these conditions.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please read the User Guide of Recombinant Proteins for more specific information.

Keywords