NKG2D/CD314 Protein, Human, Recombinant (mFc)

Catalog No. TMPY-06827

NKG2D/CD314 Protein, Human, Recombinant (mFc) is expressed in Baculovirus insect cells with mFc tag. The predicted molecular weight is 41.83 kDa and the accession number is P26718-1.

NKG2D/CD314 Protein, Human, Recombinant (mFc)

Catalog No. TMPY-06827

NKG2D/CD314 Protein, Human, Recombinant (mFc) is expressed in Baculovirus insect cells with mFc tag. The predicted molecular weight is 41.83 kDa and the accession number is P26718-1.

Pack Size	Price	Availability	Quantity
100 μg	$600	7-10 days
1 mg	$3,910	7-10 days

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Product Information

Biological Activity	Immobilized Recombinant Human MICA Protein (ECD,His Tag) at 2 μg/mL (100 μL/well) can bind Recombinant Human NKG2D Protein (ECD, mFc Tag) , the EC50 is 300-900 ng/mL.
Description	NKG2D/CD314 Protein, Human, Recombinant (mFc) is expressed in Baculovirus insect cells with mFc tag. The predicted molecular weight is 41.83 kDa and the accession number is P26718-1.
Species	Human
Expression System	Baculovirus Insect Cells
Tag	N-mFc
Accession Number	P26718-1
Synonyms	NKG2-D,NKG2D,KLR,killer cell lectin-like receptor subfamily K, member 1,D12S2489E,CD314
Construction	A DNA sequence encoding the Human KLRK1 (P26718-1) (Phe78-Val216) was expressed with the Fc region of mouse IgG1 at the N-terminus. Predicted N terminal: Ala
Protein Purity	≥ 95 % as determined by SDS-PAGE.
Molecular Weight	41.83 kDa (predicted); 46.51 kDa (reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM tris, 300 mM NaCl, 10% Glycerol, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular proteins incapable to transduce signals. To transduce signals, NKG2D needs adaptor proteins and it uses two adaptor proteins, DAP10 and DAP12. These two adaptor proteins associate as homodimers to NKG2D- therefore the entire receptor complex appears as a hexamer. NKG2D can send co-stimulatory signals to activate CD8 T cells. NKG2D also plays an important role in viral control. Cellular stress can induce ligands for NKG2D which results in the cell susceptible to NK cell-mediated lysis.