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Ropinirole
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Catalog No. T60418Cas No. 91374-21-9
Alias SKF101468, SKF 101468
Ropinirole (SKF 101468) is an orally active and potent D3/D2 receptor agonist with anti-amyotrophic lateral sclerosis effects. Ropinirole is used in the study of Parkinson's disease.
Ropinirole
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Purity: 99.68%
Catalog No. T60418Alias SKF101468, SKF 101468Cas No. 91374-21-9
Ropinirole (SKF 101468) is an orally active and potent D3/D2 receptor agonist with anti-amyotrophic lateral sclerosis effects. Ropinirole is used in the study of Parkinson's disease.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $31 | In Stock | In Stock | |
| 50 mg | $53 | In Stock | In Stock | |
| 100 mg | $80 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $35 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.68%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Ropinirole (SKF 101468) is an orally active and potent D3/D2 receptor agonist with anti-amyotrophic lateral sclerosis effects. Ropinirole is used in the study of Parkinson's disease. |
| Targets&IC50 | D4 receptor (human):6.8 (pEC50), D2 receptor (human):7.4 (pEC50), D3 receptor (human):8.4 (pEC50), D2 receptor:29 nM (Ki) |
| In vitro | Ropinirole has a 10- to 20-fold higher binding affinity for D3 receptors than for D2 and D4 receptors. As an orally potent D3/D2 receptor agonist, Ropinirole has a Ki value of 29 nM for the D2 receptor and has pEC50s of 7.4, 8.4, and 6.8 for the hD2, hD3, and hD4 receptors, respectively, with no affinity for the D1 receptor. [1] Ropinirole showed low activity at α2-adrenergic receptors and 5-HT2 receptors, but no activity at 5-HT1 receptors, benzodiazepine receptors, γ-aminobutyric acid receptors, and α1 and β-adrenergic receptors. [2] |
| In vivo | Intraperitoneal injections of Ropinirole at doses of 0.1-10 mg/kg were able to lower the threshold for intracranial self-stimulation (ICSS), showing anxiolytic and antidepressant effects without affecting motor function or spatial memory. [2] |
| Synonyms | SKF101468, SKF 101468 |
| Molecular Weight | 260.38 |
| Formula | C16H24N2O |
| Cas No. | 91374-21-9 |
| Smiles | O=C1NC2=CC=CC(=C2C1)CCN(CCC)CCC |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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