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Anti-Mouse IFNγR/CD119 Antibody (GR-20) is a rat-derived IgG2a κ inhibitory antibody that binds specifically to the α chain of mouse IFNγR (CD119) to block the interaction between IFNγ and CD119, thereby inhibiting the IFNγ-mediated signaling pathway. Anti-Mouse IFNγR/CD119 Antibody (GR-20) can be widely applied to relevant research in the fields of cancer, infectious diseases, inflammatory diseases and immunology, such as the research on the pathogenesis of melanoma and the research on genital tract inflammation induced by Chlamydia trachomatis infection .
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $163 | Inquiry | Inquiry | |
| 5 mg | $538 | Inquiry | Inquiry | |
| 10 mg | Preferential | Inquiry | Inquiry |
| Description | Anti-Mouse IFNγR/CD119 Antibody (GR-20) is a rat-derived IgG2a κ inhibitory antibody that binds specifically to the α chain of mouse IFNγR (CD119) to block the interaction between IFNγ and CD119, thereby inhibiting the IFNγ-mediated signaling pathway. Anti-Mouse IFNγR/CD119 Antibody (GR-20) can be widely applied to relevant research in the fields of cancer, infectious diseases, inflammatory diseases and immunology, such as the research on the pathogenesis of melanoma and the research on genital tract inflammation induced by Chlamydia trachomatis infection . |
| In vitro | Treatment with Anti-Mouse IFNγR/CD119 Antibody (GR-20) for 1 hour downregulates the expression level of the non-classical MHC molecule Qa-1b in B16 melanoma cells [1]. |
| In vivo | Intraperitoneal administration of Anti-Mouse IFNγR/CD119 Antibody (GR-20) (200 μg per dose, with the first dose administered 1 day prior to Chlamydia trachomatis infection and subsequent doses given every other day) induces extensive genital tract inflammation and tissue damage in infected mice [2]. |
| Synonyms | GR-20 |
| Clone | GR-20 |
| Reactivity | Mouse |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | IFNγR/CD119 |
| Molecular Weight | 150 kDa |
| Isotype | Rat IgG2a kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | Lyophilized powder: -20~-80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Size | Quantity | Unit Price | Amount | Operation |
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