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ASK1-IN-4

Name: ASK1-IN-4
Brand: TargetMol
SKU: T67857
Price: 82 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67857Cas No. 1427538-26-8

ASK1-IN-4 is an ASK1 inhibitor, IC50 = 0.2 μM.

ASK1-IN-4

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Purity: 99.75%

Catalog No. T67857Cas No. 1427538-26-8

ASK1-IN-4 is an ASK1 inhibitor, IC50 = 0.2 μM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$82	-	In Stock
5 mg	$188	-	In Stock
10 mg	$277	-	In Stock
25 mg	$413	-	In Stock
50 mg	$580	-	In Stock
100 mg	$791	-	In Stock
200 mg	$1,070	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.75%

Appearance:Solid

Color:Orange

Resource Download

COA LCMS HNMR

Product Introduction

ASK1-IN-4 AI Summary

ASK1-IN-4 exhibits a range of bioactivities across several human kinases. It strongly inhibits human Aurora A with an activity of 100.0%, and significantly inhibits human JNK3 with an activity of 92.0%. It also inhibits human HGFR with an activity of 51.0%. Moderate inhibition is noted for human CK2 and human Tie2, both at 28.0%, and for human FGFR1 at 10.0%. Low inhibition is observed for human ASK1 with an activity of 3.0%, with an IC50 value of 200.0 nM for this kinase..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	ASK1-IN-4 is an ASK1 inhibitor, IC50 = 0.2 μM.
Targets&IC50	ASK1:0.2 μM

Chemical Properties

Molecular Weight	452.34
Formula	C₁₈H₁₄BrNO₄S₂
Cas No.	1427538-26-8
Smiles	C(\C=1OC(=CC1)C2=CC=C(Br)C=C2)=C\3/C(=O)N(CCCC(O)=O)C(=S)S3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (22.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2107 mL	11.0536 mL	22.1073 mL	110.5363 mL
5 mM	0.4421 mL	2.2107 mL	4.4215 mL	22.1073 mL
10 mM	0.2211 mL	1.1054 mL	2.2107 mL	11.0536 mL
20 mM	0.1105 mL	0.5527 mL	1.1054 mL	5.5268 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc