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Lensiprazine
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Catalog No. T32633Cas No. 327026-93-7
Alias SLV-314, SLV314, SLV 314
Lensiprazine (SLV314) is a potent dopamine D(2) receptor antagonist that acts as a serotonin reuptake inhibitor , and can be used to study bipolar disorder and schizophrenia.
Lensiprazine
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Purity: 97.86%
Catalog No. T32633Alias SLV-314, SLV314, SLV 314Cas No. 327026-93-7
Lensiprazine (SLV314) is a potent dopamine D(2) receptor antagonist that acts as a serotonin reuptake inhibitor , and can be used to study bipolar disorder and schizophrenia.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $81 | In Stock | In Stock | |
| 5 mg | $202 | In Stock | In Stock | |
| 10 mg | $288 | In Stock | In Stock | |
| 25 mg | $453 | In Stock | In Stock | |
| 50 mg | $645 | In Stock | In Stock | |
| 100 mg | $882 | In Stock | In Stock | |
| 200 mg | $1,180 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:97.86%
Appearance:Solid
Color:White
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Product Introduction
Lensiprazine AI Summary
Lensiprazine exhibits diverse bioactivities, including significant inhibitory action against the dopamine D2 receptor with a Ki value of 6.9 nM and serotonin reuptake site binding with a Ki value of 0.2 nM. It is effective in reducing apomorphine-induced climbing behavior in mice, a dopaminergic antagonist action, with an ED50 of 0.08 mg/kg orally. It also potentiates 5-HTP induced serotonin syndrome in mice, indicating serotonin reuptake inhibitory activity, with an ED50 of 0.15 mg/kg orally. Lensiprazine shows high affinity for dopamine receptors D2, D3, and D4.4, serotonin receptors 5HT1A, 5HT2B, and 5HT7, as well as for the serotonin transporter. Additionally, it interacts with the adrenergic alpha1 receptor and histaminergic H1 receptor, although with slightly lower affinity. These properties indicate potential neurological and behavioral effects mediated by these receptors..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Lensiprazine (SLV314) is a potent dopamine D(2) receptor antagonist that acts as a serotonin reuptake inhibitor , and can be used to study bipolar disorder and schizophrenia. |
| Synonyms | SLV-314, SLV314, SLV 314 |
| Molecular Weight | 422.5 |
| Formula | C24H27FN4O2 |
| Cas No. | 327026-93-7 |
| Smiles | C[C@H]1OC2=C(C=CC=C2NC1=O)N3CCN(CCCC=4C=5C(NC4)=CC=C(F)C5)CC3 |
| Relative Density. | 1.262g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (118.34 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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