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Anti-Phospho-MEK1 (Thr286) Polyclonal Antibody
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Catalog No. TMAB-10981
Anti-Phospho-MEK1 (Thr286) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MEK1 (Thr286). Anti-Phospho-MEK1 (Thr286) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-MEK1 (Thr286) Polyclonal Antibody
Anti-Phospho-MEK1 (Thr286) Polyclonal Antibody
😃Good
Catalog No. TMAB-10981
Anti-Phospho-MEK1 (Thr286) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MEK1 (Thr286). Anti-Phospho-MEK1 (Thr286) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-MEK1 (Thr286) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MEK1 (Thr286). Anti-Phospho-MEK1 (Thr286) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human,Pig,Cow,Rabbit) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole body. Cytoplasm. Nucleus. Note=Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis. |
| Tissue Specificity | Widely expressed, with extremely low levels in brain. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated synthesised phosphopeptide: human MEK1 around the phosphorylation site of Thr286 |
| Antigen Species | Human |
| Gene Name | MAP2K2 |
| Gene ID | |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 2 |
| Uniprot ID | |
| Function | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. |
| Molecular Weight | Theoretical: 43 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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