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Anti-LAG-3 Antibody-PE (6Z541)
(Synonyms: lymphocyte-activation gene 3, LAG-3, CD223) Copy Product Info
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Synonyms: lymphocyte-activation gene 3, LAG-3, CD223
Catalog No. TMAY-02828P Copy Product Info
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Anti-LAG-3 Antibody-PE (6Z541) is a PE-conjugated Mouse antibody targeting LAG-3. Anti-LAG-3 Antibody-PE (6Z541) can be used in FCM.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 T | $81 | 7-10 days | 7-10 days | |
| 100 T | $175 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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| Description | Anti-LAG-3 Antibody-PE (6Z541) is a PE-conjugated Mouse antibody targeting LAG-3. Anti-LAG-3 Antibody-PE (6Z541) can be used in FCM. |
| Synonyms | lymphocyte-activation gene 3, LAG-3, CD223 |
| Ig Type | Mouse IgG1 |
| Clone | 6Z541 |
| Reactivity | Human |
| Specificity | Human LAG-3 |
| Verified Activity | Flow cytometric analysis of Human LAG3 expression on human peripheral blood lymphocytes. Human peripheral blood mononulcear cells were stimulated for 72 hours with CD3 and CD28, then stained with PE-conjugated anti-Human LAG3. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| Application | |
| Recommended Dose | 5 μL/Test, 0.1 mg/mL |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This product is a recombinant monoclonal antibody expressed from HEK293 cells, and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| Conjucates | PE |
| Immunogen | Recombinant Protein: Human LAG3 Protein |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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