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beta-MSH, human

Name: beta-MSH, human
Brand: TargetMol
SKU: TP1004
Price: 148 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1004Cas No. 17908-57-5

Alias β-MSH, human, β-Melanocyte Stimulating Hormone (MSH), human

beta-MSH, human is an endogenous peptide hormone and neurotransmitter produced by pro-opiomelanocortin (POMC), and is also an agonist of MC4-R (melanocortin 4 receptor).

beta-MSH, human

😃Good

Catalog No. TP1004Alias β-MSH, human, β-Melanocyte Stimulating Hormone (MSH), humanCas No. 17908-57-5

beta-MSH, human is an endogenous peptide hormone and neurotransmitter produced by pro-opiomelanocortin (POMC), and is also an agonist of MC4-R (melanocortin 4 receptor).

Pack Size	Price	Availability
1 mg	$148	In Stock
5 mg	$445	Backorder
10 mg	$751	Backorder

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	beta-MSH, human is an endogenous peptide hormone and neurotransmitter produced by pro-opiomelanocortin (POMC), and is also an agonist of MC4-R (melanocortin 4 receptor).
In vitro	In human THP-1 monocytic cells, beta-MSH (0.1–100 nM) suppressed lipopolysaccharide (LPS, 10 ng/mL)-induced TNF-α production in a concentration-dependent manner, with maximal inhibition observed at 1–10 nM. beta-MSH did not significantly alter IL-10 expression but reduced proinflammatory cytokine production via activation of melanocortin receptors, particularly MC1R and MC3R[1].
In vivo	In mouse models, intraperitoneal injection of beta-MSH (0.5 mg/kg) significantly reduced plasma TNF-α levels induced by LPS (0.5 mg/kg) and attenuated inflammatory responses[1].
Alias	β-MSH, human, β-Melanocyte Stimulating Hormone (MSH), human

Chemical Properties

Molecular Weight	2660.92
Formula	C₁₁₈H₁₇₄N₃₄O₃₅S
Cas No.	17908-57-5
Smiles	C([C@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CN=CN2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]3N(C(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)N)=O)CCC(O)=O)=O)CCCCN)=O)CCCCN)=O)CC(O)=O)=O)CCC(O)=O)=O)=O)CCC3)CC4=CC=C(O)C=C4)=O)CCCNC(=N)N)=O)CCSC)=O)CCC(O)=O)=O)=O)=O)CCCNC(=N)N)=O)C(NCC(N[C@H](C(=O)N5[C@H](C(=O)N6[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)CCCCN)=O)CCC6)CCC5)CO)=O)=O)C=7C=8C(NC7)=CC=CC8
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (18.79 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.3758 mL	1.8790 mL	3.7581 mL	18.7905 mL
5 mM	0.0752 mL	0.3758 mL	0.7516 mL	3.7581 mL
10 mM	0.0376 mL	0.1879 mL	0.3758 mL	1.8790 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

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For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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