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beta-MSH, human

Name: beta-MSH, human
Brand: TargetMol
SKU: TP1004
Price: 148 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1004Cas No. 17908-57-5

Alias β-MSH, human, β-Melanocyte Stimulating Hormone (MSH), human

beta-MSH, human is an endogenous peptide hormone and neurotransmitter produced by pro-opiomelanocortin (POMC), and is also an agonist of MC4-R (melanocortin 4 receptor).

beta-MSH, human

😃Good

Catalog No. TP1004Alias β-MSH, human, β-Melanocyte Stimulating Hormone (MSH), humanCas No. 17908-57-5

beta-MSH, human is an endogenous peptide hormone and neurotransmitter produced by pro-opiomelanocortin (POMC), and is also an agonist of MC4-R (melanocortin 4 receptor).

Pack Size	Price	Availability
1 mg	$148	In Stock
5 mg	$445	Backorder
10 mg	$751	Backorder

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Product Introduction

Bioactivity

Description	beta-MSH, human is an endogenous peptide hormone and neurotransmitter produced by pro-opiomelanocortin (POMC), and is also an agonist of MC4-R (melanocortin 4 receptor).
In vitro	In human THP-1 monocytic cells, beta-MSH (0.1–100 nM) suppressed lipopolysaccharide (LPS, 10 ng/mL)-induced TNF-α production in a concentration-dependent manner, with maximal inhibition observed at 1–10 nM. beta-MSH did not significantly alter IL-10 expression but reduced proinflammatory cytokine production via activation of melanocortin receptors, particularly MC1R and MC3R[1].
In vivo	In mouse models, intraperitoneal injection of beta-MSH (0.5 mg/kg) significantly reduced plasma TNF-α levels induced by LPS (0.5 mg/kg) and attenuated inflammatory responses[1].
Alias	β-MSH, human, β-Melanocyte Stimulating Hormone (MSH), human

Chemical Properties

Molecular Weight	2660.92
Formula	C₁₁₈H₁₇₄N₃₄O₃₅S
Cas No.	17908-57-5
Smiles	C([C@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CN=CN2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]3N(C(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)N)=O)CCC(O)=O)=O)CCCCN)=O)CCCCN)=O)CC(O)=O)=O)CCC(O)=O)=O)=O)CCC3)CC4=CC=C(O)C=C4)=O)CCCNC(=N)N)=O)CCSC)=O)CCC(O)=O)=O)=O)=O)CCCNC(=N)N)=O)C(NCC(N[C@H](C(=O)N5[C@H](C(=O)N6[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)CCCCN)=O)CCC6)CCC5)CO)=O)=O)C=7C=8C(NC7)=CC=CC8
Relative Density.	no data available
Sequence	Ala-Glu-Lys-Lys-Asp-Glu-Gly-Pro-Tyr-Arg-Met-Glu-His-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp
Sequence Short	AEKKDEGPYRMEHFRWGSPPKD

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (18.79 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.3758 mL	1.8790 mL	3.7581 mL	18.7905 mL
5 mM	0.0752 mL	0.3758 mL	0.7516 mL	3.7581 mL
10 mM	0.0376 mL	0.1879 mL	0.3758 mL	1.8790 mL

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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