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Ceftazidime

Name: Ceftazidime
Brand: TargetMol
SKU: T1305
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1305Cas No. 72558-82-8

Alias GR20263

Ceftazidime (GR20263) is a beta-lactam, cephalosporin antibiotic with bactericidal activity.

Ceftazidime

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Purity: 99.85%

Catalog No. T1305Alias GR20263Cas No. 72558-82-8

Ceftazidime (GR20263) is a beta-lactam, cephalosporin antibiotic with bactericidal activity.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$41	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.85%

Color:White

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Product Introduction

Ceftazidime AI Summary

Ceftazidime demonstrates broad-spectrum antimicrobial activity against a variety of bacterial strains, including Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, Acinetobacter baumannii, Staphylococcus aureus, and several others. The compound shows varying levels of minimum inhibitory concentration (MIC) values, ranging from as low as 0.03 ug/mL to over 256.0 ug/mL, depending on the specific bacterial strain and their resistance mechanisms. It is particularly potent against certain beta-lactamase producing strains, such as those with CTX-M, TEM, and SHV enzymes, and has shown inhibition of bacterial growth even in the presence of resistance genes like OXA, VIM, and KPC. The compound exhibits effectiveness in both in vitro and in vivo models, with additional pharmacokinetic data indicating a short plasma half-life and significant urinary recovery, especially in rats and marmosets. Moreover, Ceftazidime demonstrates synergy with beta-lactamase inhibitors like clavulanic acid, enhancing its antibacterial effects. Despite its promising antimicrobial properties, the compound shows reduced efficacy against specific resistant strains such as imipenem-resistant Acinetobacter baumannii and certain multidrug-resistant Pseudomonas aeruginosa isolates. Overall, Ceftazidime holds potential as a valuable antimicrobial agent capable of combating a wide range of bacterial infections, particularly those involving beta-lactamase producing and multidrug-resistant pathogens. Further studies into its mechanism of action, optimal dosing strategies, and combination therapies could expand its clinical utility..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ceftazidime (GR20263) is a beta-lactam, cephalosporin antibiotic with bactericidal activity.
Synonyms	GR20263

Chemical Properties

Molecular Weight	546.58
Formula	C₂₂H₂₂N₆O₇S₂
Cas No.	72558-82-8
Smiles	CC(C)(O\N=C(/C(=O)N[C@H]1[C@H]2SCC(C[n+]3ccccc3)=C(N2C1=O)C(O)=O)c1csc(=N)[nH]1)C([O-])=O
Relative Density.	no data available

Storage & Solubility Information

Storage

store under nitrogen,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20.1 mg/mL (36.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.66 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8296 mL	9.1478 mL	18.2956 mL	91.4779 mL
5 mM	0.3659 mL	1.8296 mL	3.6591 mL	18.2956 mL
10 mM	0.1830 mL	0.9148 mL	1.8296 mL	9.1478 mL
20 mM	0.0915 mL	0.4574 mL	0.9148 mL	4.5739 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc