Shopping Cart

Your shopping cart is currently empty

Leonurine hydrochloride

Name: Leonurine hydrochloride
Brand: TargetMol
SKU: T4080
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T4080Cas No. 24735-18-0

Alias SCM-198 hydrochloride, SCM-198 HCl

Leonurine hydrochloride (SCM-198 hydrochloride) , a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.

Leonurine hydrochloride

Copy Product Info

😃Good

Purity: 99.97%

Catalog No. T4080Alias SCM-198 hydrochloride, SCM-198 HClCas No. 24735-18-0

Leonurine hydrochloride (SCM-198 hydrochloride) , a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$31	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$106	In Stock	In Stock
50 mg	$139	In Stock	In Stock
100 mg	$179	In Stock	In Stock
500 mg	$455	-	In Stock
1 mL x 10 mM (in DMSO)	$40	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.97%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Leonurine hydrochloride (SCM-198 hydrochloride) , a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
In vitro	The treatment of Leonurine hydrochloride (10-50?μM) for 24?h increases apoptotic ratio from 4.9% to 11.5-61.3%, respectively. The inhibition effect of Leonurine hydrochloride on H292 cells is related to the generation of ROS and the loss of MMP. Leonurine hydrochloride can increase the phosphorylation level of p38 and reduce Akt phosphorylation. Furthermore, Leonurine hydrochloride treatment increases the expression levels of caspase-3, caspase-9 and Bax/Bcl-2[1]. In RAW 264.7 cells and mouse bone marrow monocytes (BMMs), Leonurine hydrochloride suppresses RANKL-induced osteoclastogenesis and actin ring formation in a dose-dependent manner [2].
In vivo	Leonurine hydrochloride can elevate the ET level and ET/NO ratio in rats with up-regulated ETA mRNA expression and induced abortions, but there is no change in ETB mRNA[3]. Compared with the model group, Leonurine hydrochloride treatment markedly reduces the volume of bleeding and intrauterine residual, and markedly shortens the duration of bleeding. Leonurine hydrochloride also obviously reinforces the tension and frequency of uterine contractions [4].
Synonyms	SCM-198 hydrochloride, SCM-198 HCl

Chemical Properties

Molecular Weight	347.79
Formula	C₁₄H₂₂ClN₃O₅
Cas No.	24735-18-0
Smiles	Cl.COc1cc(cc(OC)c1O)C(=O)OCCCCNC=NN
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (287.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (9.49 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8753 mL	14.3765 mL	28.7530 mL	143.7649 mL
5 mM	0.5751 mL	2.8753 mL	5.7506 mL	28.7530 mL
10 mM	0.2875 mL	1.4376 mL	2.8753 mL	14.3765 mL
20 mM	0.1438 mL	0.7188 mL	1.4376 mL	7.1882 mL
50 mM	0.0575 mL	0.2875 mL	0.5751 mL	2.8753 mL
100 mM	0.0288 mL	0.1438 mL	0.2875 mL	1.4376 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc