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Anti-DNA Ligase IV Antibody (5M82)
😃Good
Catalog No. TMAB-05212
Anti-DNA Ligase IV Antibody (5M82) is a Rabbit antibody targeting DNA Ligase IV. Anti-DNA Ligase IV Antibody (5M82) can be used in IF, IHC-Fr, IHC-P, WB.
Anti-DNA Ligase IV Antibody (5M82)
Anti-DNA Ligase IV Antibody (5M82)
😃Good
Catalog No. TMAB-05212
Anti-DNA Ligase IV Antibody (5M82) is a Rabbit antibody targeting DNA Ligase IV. Anti-DNA Ligase IV Antibody (5M82) can be used in IF, IHC-Fr, IHC-P, WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $261 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-DNA Ligase IV Antibody (5M82) is a Rabbit antibody targeting DNA Ligase IV. Anti-DNA Ligase IV Antibody (5M82) can be used in IF, IHC-Fr, IHC-P, WB. |
| Ig Type | IgG |
| Clone | 5M82 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IF=1:50-200; IHC-Fr=1:50-200; IHC-P=1:50-200; WB=1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Testis, thymus, prostate and heart. |
| Tissue Specificity | Testis, thymus, prostate and heart. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The X-ray repair cross-complementing protein XRCC4 and DNA Ligase IV are essential for repairing double-strand breaks in DNA. These proteins form a critical complex consisting of two molecules of each protein that preferentially bind DNA with nicks or broken ends. As an obligate accessory molecule, XRCC4 binds to DNA Ligase IV and enhances its joining activity. The XRCC4/ DNA Ligase IV complex is also involved in V(D)J recombination. V(D)J recombination occurs in normal development of the adaptive immune system and involves the formation of a double-strand break intermediate. Deletions of either DNA Ligase IV or XRCC4 inhibit the completion of V(D)J recombination, resulting in a high incidence of apoptosis in the developing nervous system and a block in B and T cell maturation. |
| Immunogen | Recombinant Protein: human DNA Ligase IV |
| Antigen Species | Human |
| Gene Name | LIG4 |
| Gene ID | |
| Protein Name | DNA ligase 4 |
| Uniprot ID | |
| Function | Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. |
| Molecular Weight | Theoretical: 104 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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