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DSPE-PEG2000-iRGD
Catalog No. TCL-01137 Copy Product Info
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DSPE-PEG2000-iRGD is a functionalized lipid composed of DSPE, PEG chain and iRGD peptide targeting αv- integrin. IRGD peptide binds to αv- integrin and undergoes proteolysis in tumor microenvironment to generate CendR motif (CRGDK/R), which then interacts with neuropilin-1, thus endowing it with tumor targeting and tissue penetration ability, and is often used in the study of active molecule delivery.
DSPE-PEG2000-iRGD
Copy Product Info🥰Excellent
Catalog No. TCL-01137
DSPE-PEG2000-iRGD is a functionalized lipid composed of DSPE, PEG chain and iRGD peptide targeting αv- integrin. IRGD peptide binds to αv- integrin and undergoes proteolysis in tumor microenvironment to generate CendR motif (CRGDK/R), which then interacts with neuropilin-1, thus endowing it with tumor targeting and tissue penetration ability, and is often used in the study of active molecule delivery.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $148 | - | In Stock | |
| 5 mg | $368 | - | In Stock | |
| 10 mg | $546 | - | In Stock | |
| 25 mg | $1,090 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Appearance:Solid
Color:White
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Storage & Solubility Information
| Description | DSPE-PEG2000-iRGD is a functionalized lipid composed of DSPE, PEG chain and iRGD peptide targeting αv- integrin. IRGD peptide binds to αv- integrin and undergoes proteolysis in tumor microenvironment to generate CendR motif (CRGDK/R), which then interacts with neuropilin-1, thus endowing it with tumor targeting and tissue penetration ability, and is often used in the study of active molecule delivery. |
| In vitro | DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and αv- integrin targeting peptide (iRGD). IRGD peptide binds to αv- integrin, and then the protein is hydrolyzed and cleaved in tumor to produce the interaction between CRGDK/R and Neuropin-1, which has the characteristics of tumor targeting and tumor penetration [1]. M-SAL-IRGD (DSPE-PEG2000 nano micelle coupled with IRGD) constructed by DSPE-PEG2000-iRGD is used for targeted delivery of Salinomycin to interfere with liver cancer cells and cancer stem cells [2]. |
| In vivo | IRGD-LP-CUR-PIP constructed by DSPE-PEG2000-iRGD is a peptide liposome penetrated by tumor, which shows anti-tumor effect, mainly by significantly reducing tumor volume and increasing body weight and spleen index [3]. |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility Information | DMSO: 100 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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