L-Ornithine ((S)-2, 5-diaminopentanoic acid) is a non-protein amino acid. L-Ornithine is mainly used in the urea cycle to remove excess nitrogen from the body. L-Ornithine is renoprotective. L-Ornithine has antifatigue effects.

Arginase (bovine):1.02 mM (Ki)

METHODS: HK-2 cells were treated with L-Ornithine (100, 300 μM) for 24 hours, and ROS levels were measured using fluorescence microscopy.
RESULTS: Ornithine protected HK-2 cells from ROS production. [1]

METHODS: To investigate the effect of L-Ornithine on peripheral clock gene expression, mice were orally treated with L-Ornithine (1000 mg/kg) for 3 days.
RESULTS: The phase of PER2 gene expression in liver, submandibular gland and kidney was significantly advanced in L-Ornithine treated mice. [2]
METHODS: To investigate the effect of L-Ornithine on sleep behavior, L-Ornithine was added to the diet of maternal mice, and its effect on the sleep behavior of offspring mice was observed.
RESULTS: L-Ornithine supplementation increased sleep-like behavior in mice. [3]
METHODS: To study the effect of L-Ornithine on acute necrotizing pancreatitis, rats were intraperitoneally injected with L-Ornithine (3 g/kg).
RESULTS: Severe acute necrotizing pancreatitis was induced by L-Ornithine in rats. [4]