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UCL-TRO-1938

Name: UCL-TRO-1938
Brand: TargetMol
SKU: T78092
Price: 123 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78092Cas No. 2919575-27-0

UCL-TRO-1938 is a subtype-selective PI3Kα allosteric activator with cardioprotective and neuroregenerative effects. UCL-TRO-1938 can induce cell proliferation and can be used to study diseases caused by abnormal PI3Kα metabolism.

UCL-TRO-1938

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Purity: 99.95%

Catalog No. T78092Cas No. 2919575-27-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$123	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$413	In Stock	In Stock
50 mg	$662	-	In Stock
100 mg	$1,060	-	In Stock
200 mg	$1,420	-	In Stock
1 mL x 10 mM (in DMSO)	$123	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.95%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	UCL-TRO-1938 is a subtype-selective PI3Kα allosteric activator with cardioprotective and neuroregenerative effects. UCL-TRO-1938 can induce cell proliferation and can be used to study diseases caused by abnormal PI3Kα metabolism.
In vitro	In PI3Kα-WT but not in PI3Kα-KO MEFs, 24h treatment with UCL-TRO-1938 dose-dependently increased metabolic activity, with an EC50 of ~0.5 μM, and a decrease in ATP levels in both PI3Kα-WT and PI3Kα-KO MEFs at concentrations >7.5 μM, indicative of PI3Kα-independent effects of UCL-TRO-1938 at these doses. [1]
In vivo	Male C57/BL6 mice weighing 25-30 g were used throughout. 10 mg/kg UCL-TRO-1938 compound in DMSO. UCL-TRO-1938 provided significant cardioprotection in an in vivo IRI model in mice, with a corresponding pAKTS473 increase in the hearts. [1]

Chemical Properties

Molecular Weight	456.58
Formula	C₂₇H₃₂N₆O
Cas No.	2919575-27-0
Smiles	O=C(N1C=2C(=CC=CC2CC1)NC=3C=CN=C(C3)NC4=CC=C(C=C4)N5CCN(CC)CC5)C

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (54.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.38 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1902 mL	10.9510 mL	21.9020 mL	109.5098 mL
5 mM	0.4380 mL	2.1902 mL	4.3804 mL	21.9020 mL
10 mM	0.2190 mL	1.0951 mL	2.1902 mL	10.9510 mL
20 mM	0.1095 mL	0.5475 mL	1.0951 mL	5.4755 mL
50 mM	0.0438 mL	0.2190 mL	0.4380 mL	2.1902 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc