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INT-777 R-enantiomer

Name: INT-777 R-enantiomer
Brand: TargetMol
SKU: T11662
Rating: 4.5 (1 reviews)

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Catalog No. T11662Cas No. 1198786-98-9

Alias S-EMCA R enantiomer

INT-777 is the R-enantiomer of INT-777, less potent than INT-777,EC50 of 4.79 μM for TGR5.

INT-777 R-enantiomer

😃Good

Catalog No. T11662Alias S-EMCA R enantiomerCas No. 1198786-98-9

INT-777 is the R-enantiomer of INT-777, less potent than INT-777,EC50 of 4.79 μM for TGR5.

Pack Size	Price	Availability
25 mg	$1,820	8-10 weeks
50 mg	$2,380	8-10 weeks
100 mg	$3,100	8-10 weeks

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Product Introduction

Bioactivity

Description	INT-777 is the R-enantiomer of INT-777, less potent than INT-777,EC50 of 4.79 μM for TGR5.
In vivo	INT-777 is more choleretic than CA, but less than INT-777.
Synonyms	S-EMCA R enantiomer

Chemical Properties

Molecular Weight	450.65
Formula	C₂₇H₄₆O₅
Cas No.	1198786-98-9
Relative Density.	1.128 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (221.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2190 mL	11.0951 mL	22.1902 mL	110.9508 mL
5 mM	0.4438 mL	2.2190 mL	4.4380 mL	22.1902 mL
10 mM	0.2219 mL	1.1095 mL	2.2190 mL	11.0951 mL
20 mM	0.1110 mL	0.5548 mL	1.1095 mL	5.5475 mL
50 mM	0.0444 mL	0.2219 mL	0.4438 mL	2.2190 mL
100 mM	0.0222 mL	0.1110 mL	0.2219 mL	1.1095 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc