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Neuregulin-1/NRG1 Protein, Canine, Recombinant (mFc)
(Synonyms: neuregulin 1) Copy Product InfoSynonyms: neuregulin 1
Catalog No. TMPY-03902 Copy Product Info
Neuregulin-1/NRG1 Protein, Canine, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 34 kDa and the accession number is XP_858147.1.
| Pack Size | Price | EUR Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | 36 € | - | In Stock | |
| 10 µg | 54 € | 7-10 days | 7-10 days | |
| 20 µg | 86 € | - | In Stock | |
| 50 µg | 164 € | - | In Stock | |
| 100 µg | 275 € | - | In Stock |
For In stock only · Estimated delivery: EUR Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Appearance:Lyophilized powder
Color:White
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Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 for this effect is typically 0.1-1 µg/mL. |
| Description | Neuregulin-1/NRG1 Protein, Canine, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 34 kDa and the accession number is XP_858147.1. |
| Species | Canine |
| Expression System | HEK293 Cells |
| Tag | N-mFc |
| Accession Number | XP_858147.1 |
| Construction | A DNA sequence encoding the canine NRG1 (XP_858147.1) EGF-like domain (Ser176-Lys240) was expressed with the Fc region of mouse IgG1 at the N-terminus. Predicted N terminal: Asp |
| Protein Purity | > 95 % as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Synonyms | neuregulin 1 |
| Research Background | Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. |
| Molecular Weight | 34 kDa (predicted); 37 and 34 kDa (reducing conditions) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: Neuregulin-1/NRG1 Protein, Canine, Recombinant (mFc) chemical structure | Neuregulin-1/NRG1 Protein, Canine, Recombinant (mFc) molecular weight
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