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Ziresovir

Name: Ziresovir
Brand: TargetMol
SKU: T13401
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: RO-0529, AK0529) Copy Product Info

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Synonyms: RO-0529, AK0529

Catalog No. T13401 Copy Product Info

Purity: 99.98%

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Ziresovir (RO-0529/AK0529) belongs to small molecule inhibitors and is a respiratory syncytial virus (RSV) fusion protein (F protein) inhibitor (EC50 = 3 nM) with oral activity and selectivity. This compound is used in research on respiratory syncytial virus infection, significantly alleviating bronchitis symptoms and reducing viral load.

Cas No. 1422500-60-4

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Pack Size	Price	USA Stock	Global Stock
2 mg	$97	In Stock	In Stock
5 mg	$162	In Stock	In Stock
10 mg	$247	In Stock	In Stock
25 mg	$397	In Stock	In Stock
50 mg	$569	In Stock	In Stock
100 mg	$786	-	In Stock
1 mL x 10 mM (in DMSO)	$178	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.98%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Ziresovir (RO-0529/AK0529) belongs to small molecule inhibitors and is a respiratory syncytial virus (RSV) fusion protein (F protein) inhibitor (EC50 = 3 nM) with oral activity and selectivity. This compound is used in research on respiratory syncytial virus infection, significantly alleviating bronchitis symptoms and reducing viral load.
Targets & IC50	D486N (RSV,Mutant strain):2.1 μM (EC50), RSV (WT):0.003 μM (EC50), D489A (RSV,Mutant strain):> 10μM (EC50), RSV F:3 nM (EC50)
In vitro	Methods: In HEp-2 cells, Ziresovir (0.003–0.004 μM) was administered for 5 days, and cytopathic effect assay was used for detection. Results: The EC50 of Ziresovir against RSV Long, A2, B18537 laboratory strains and clinical isolates was 0.002–0.004 μM.[1] Methods: In HEp-2 cells, Ziresovir (0.03–3 nM) was co-incubated with RSV-Luc for 48 hours, and antiviral activity was determined by luciferase activity assay. Results: Ziresovir inhibited viral replication in a concentration-dependent manner, with an IC50 of approximately 0.2 nM, and no cytotoxicity was observed.[2]
In vivo	Methods: In a female BALB/c mouse RSV infection model, Ziresovir was administered orally at doses of 12.5 mg/kg and 50 mg/kg twice daily for 4 consecutive days. Results: Viral titers were reduced by more than 1 log at the 12.5 mg/kg dose, and decreased to 1.9 log at the 50 mg/kg dose.[1]
Synonyms	RO-0529, AK0529

Chemical Properties

Molecular Weight	439.53
Formula	C₂₂H₂₅N₅O₃S
Cas No.	1422500-60-4
Smiles	Cc1ccc2nc(nc(NCC3(N)COC3)c2c1)N1CCS(=O)(=O)c2ccccc2C1
Relative Density.	1.390 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 38 mg/mL (86.46 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2752 mL	11.3758 mL	22.7516 mL	113.7579 mL
5 mM	0.4550 mL	2.2752 mL	4.5503 mL	22.7516 mL
10 mM	0.2275 mL	1.1376 mL	2.2752 mL	11.3758 mL
20 mM	0.1138 mL	0.5688 mL	1.1376 mL	5.6879 mL
50 mM	0.0455 mL	0.2275 mL	0.4550 mL	2.2752 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.