Mal-PEG4-OH

Name: Mal-PEG4-OH
Brand: TargetMol
SKU: T15992
Rating: 4.5 (1 reviews)

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Catalog No. T15992Cas No. 1421933-37-0

Mal-PEG4-OH, a PEG-based linker for PROTACs, joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-PEG4-OH

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Catalog No. T15992Cas No. 1421933-37-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$40	Inquiry	Inquiry
10 mg	$55	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description	Mal-PEG4-OH, a PEG-based linker for PROTACs, joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
In vitro	PROTACs utilize two distinct ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].

Chemical Properties

Molecular Weight	273.28
Formula	C₁₂H₁₉NO₆
Cas No.	1421933-37-0
Smiles	O=C1C=CC(=O)N1CCOCCOCCOCCO
Relative Density.	1.246 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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