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GR79236

Name: GR79236
Brand: TargetMol
SKU: TQ0136
Rating: 4.5 (1 reviews)

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Catalog No. TQ0136Cas No. 124555-18-6

Alias GR 79236

GR79236 is an effective and selective adenosine A1 receptor agonist (Ki: 3.1 nM) that has analgesic and anti-inflammatory actions.

GR79236

😃Good

Catalog No. TQ0136Alias GR 79236Cas No. 124555-18-6

GR79236 is an effective and selective adenosine A1 receptor agonist (Ki: 3.1 nM) that has analgesic and anti-inflammatory actions.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$49	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	GR79236 is an effective and selective adenosine A1 receptor agonist (Ki: 3.1 nM) that has analgesic and anti-inflammatory actions.
Targets&IC50	A1 receptor:3.1 nM (cell free)
In vivo	GR79236 has been shown to have antinociceptive and anti-inflammatory properties in animal models. GR79236 inhibits the release of CGRP evoked by superior sagittal sinus (SSS) stimulation in the cat and inhibits trigeminal nucleus firing in the cat and rat. GR79236X has acute, short-term analgesic efficacy.
Synonyms	GR 79236

Chemical Properties

Molecular Weight	351.36
Formula	C₁₅H₂₁N₅O₅
Cas No.	124555-18-6
Smiles	OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N[C@H]3CCC[C@@H]3O)ncnc12
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 98 mg/mL (278.92 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.8461 mL	14.2304 mL	28.4608 mL	142.3042 mL
5 mM	0.5692 mL	2.8461 mL	5.6922 mL	28.4608 mL
10 mM	0.2846 mL	1.4230 mL	2.8461 mL	14.2304 mL
20 mM	0.1423 mL	0.7115 mL	1.4230 mL	7.1152 mL
50 mM	0.0569 mL	0.2846 mL	0.5692 mL	2.8461 mL
100 mM	0.0285 mL	0.1423 mL	0.2846 mL	1.4230 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc