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AZD7624

🥰Excellent
Catalog No. T14381Cas No. 1095004-78-6
Alias AZD-7624

AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.

AZD7624

AZD7624

🥰Excellent
Purity: 98.82%
Catalog No. T14381Alias AZD-7624Cas No. 1095004-78-6
AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$67In StockIn Stock
5 mg$163In StockIn Stock
10 mg$263In StockIn Stock
25 mg$479In StockIn Stock
50 mg$718In StockIn Stock
100 mg$1,070In StockIn Stock
1 mL x 10 mM (in DMSO)$178In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.82%
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Product Introduction

Bioactivity
Description
AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.
Targets&IC50
TNF-α:8.4(human mononuclear cells), 8.1(whole blood), 9.0 (alveolar macrophages)
In vitro
AZD7624 effectively suppresses LPS-induced TNFα production in human mononuclear cells, whole blood, and alveolar macrophages in vitro, exhibiting potent anti-inflammatory activity. This inhaled p38 inhibitor demonstrates significant efficacy with pIC50 values of 8.4, 8.1, and 9.0[1], respectively, highlighting its potential therapeutic application.
SynonymsAZD-7624
Chemical Properties
Molecular Weight491.56
FormulaC27H30FN5O3
Cas No.1095004-78-6
SmilesCNCCOc1ccccc1C1(CC1)Nc1nccn(-c2cc(cc(F)c2C)C(=O)NC2CC2)c1=O
Relative Density.1.36 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (101.72 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.07 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0343 mL10.1717 mL20.3434 mL101.7170 mL
5 mM0.4069 mL2.0343 mL4.0687 mL20.3434 mL
10 mM0.2034 mL1.0172 mL2.0343 mL10.1717 mL
20 mM0.1017 mL0.5086 mL1.0172 mL5.0858 mL
50 mM0.0407 mL0.2034 mL0.4069 mL2.0343 mL
100 mM0.0203 mL0.1017 mL0.2034 mL1.0172 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TNF-αp38MAPKp38 MAPKp38InhibitorinhibitAZD7624AZD 7624Autophagy
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