JTT 551

Name: JTT 551
Brand: TargetMol
SKU: T11730
Rating: 4.5 (1 reviews)

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Catalog No. T11730Cas No. 776309-04-7

JTT 551 can be used in the research of type 2 diabetes mellitus. JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively.

JTT 551

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Catalog No. T11730Cas No. 776309-04-7

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,970	8-10 weeks	8-10 weeks
50 mg	$2,580	8-10 weeks	8-10 weeks
100 mg	$3,400	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	JTT 551 can be used in the research of type 2 diabetes mellitus. JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively.
Targets&IC50	PTP1B:0.22 μM , TCPTP:9.3 μM
In vitro	JTT-551 exhibits low affinity for CD45 protein tyrosine phosphatase (CD45) and leucocyte common antigen-related (LAR) protein tyrosine phosphatase, with dissociation constants (Kis) greater than 30 μM for both. Simultaneously, it enhances insulin-induced deoxyglucose uptake in a dose-dependent manner at concentrations of 10 and 30 μM. Primarily, JTT-551 acts as a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B), demonstrating Kis of 0.22 μM for PTP1B and 9.3 μM for T-cell protein tyrosine phosphatase (TCPTP), thereby indicating its specificity and potential therapeutic utility in modulating insulin sensitivity.
In vivo	JTT 551 effectively lowers triglyceride (TG) levels at a dosage of 30 mg/kg by Day 7, without impacting insulin and total cholesterol (TC) levels. Additionally, at dosages of 3 mg/kg and 30 mg/kg administered orally (p.o.), this compound demonstrates a dose-dependent reduction in blood glucose levels in db/db mice across multiple time points, specifically on Days 7, 14, and 28.

Chemical Properties

Molecular Weight	605.85
Formula	C₃₄H₄₃N₃O₃S₂
Cas No.	776309-04-7
Smiles	CCCC(CCC)c1ccc(OCc2ccc(cc2)-c2csc(CN(CC(O)=O)Cc3ncc(s3)C(C)(C)C)n2)cc1
Relative Density.	1.174 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc