store at low temperature
store at -80°C
Garadacimab (CSL312) is a potent whole-human IgG4 monoclonal antibody targeting activation factor XII (FXIIa). Garadacimab can be used to study hereditary angioedema.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 313.00 | |
5 mg | In stock | $ 647.00 | |
10 mg | In stock | $ 987.00 | |
25 mg | In stock | $ 1,460.00 | |
50 mg | In stock | $ 1,970.00 | |
100 mg | In stock | $ 2,660.00 |
Description | Garadacimab (CSL312) is a potent whole-human IgG4 monoclonal antibody targeting activation factor XII (FXIIa). Garadacimab can be used to study hereditary angioedema. |
Targets&IC50 | β-FXIIa:140 pM(Kd) |
In vitro | Garadacimab (CSL312) demonstrates high affinity to activated βFXIIa with a KD of 140 pM. In an activated partial thromboplastin time (aPTT) assay with human plasma, Garadacimab exhibits potency. Notably, it displays high selectivity over a panel of relevant human serine proteases, including FVIIa, FIXa, FXa, FXIa, kallikrein, tissue plasminogen activator, activated protein C, and urokinase plasminogen activator[2]. |
In vivo | In male and female cynomolgus monkeys, Garadacimab (0.5, 1, and 3 mg/kg i.v. and 6 and 20 mg/kg s.c. over 8 weeks) shows a dose-dependent increase in plasma concentrations[1]. Garadacimab exhibits an inhibitory effect on FXII-mediated kallikrein activity. Moreover, it induces a clear dose-dependent prolongation of activated partial thromboplastin time (aPTT) with no associated effect on the prothrombin time[1]. |
Synonyms | CSL312 |
Molecular Weight | N/A |
CAS No. | 2162134-62-3 |
store at low temperature
store at -80°C
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Garadacimab 2162134-62-3 Metabolism Factor Xa CSL312 CSL-312 CSL 312 inhibitor inhibit