Select your Country or Region

  • TargetMol | Compound LibraryArgentinaArgentina
  • TargetMol | Compound LibraryAustraliaAustralia
  • TargetMol | Compound LibraryAustriaAustria
  • TargetMol | Compound LibraryBelgiumBelgium
  • TargetMol | Compound LibraryBrazilBrazil
  • TargetMol | Compound LibraryBulgariaBulgaria
  • TargetMol | Compound LibraryCroatiaCroatia
  • TargetMol | Compound LibraryCyprusCyprus
  • TargetMol | Compound LibraryCzechCzech
  • TargetMol | Compound LibraryDenmarkDenmark
  • TargetMol | Compound LibraryEgyptEgypt
  • TargetMol | Compound LibraryEstoniaEstonia
  • TargetMol | Compound LibraryFinlandFinland
  • TargetMol | Compound LibraryFranceFrance
  • TargetMol | Compound LibraryGermanyGermany
  • TargetMol | Compound LibraryGreeceGreece
  • TargetMol | Compound LibraryHong KongHong Kong
  • TargetMol | Compound LibraryHungaryHungary
  • TargetMol | Compound LibraryIcelandIceland
  • TargetMol | Compound LibraryIndiaIndia
  • TargetMol | Compound LibraryIrelandIreland
  • TargetMol | Compound LibraryIsraelIsrael
  • TargetMol | Compound LibraryItalyItaly
  • TargetMol | Compound LibraryJapanJapan
  • TargetMol | Compound LibraryKoreaKorea
  • TargetMol | Compound LibraryLatviaLatvia
  • TargetMol | Compound LibraryLebanonLebanon
  • TargetMol | Compound LibraryMalaysiaMalaysia
  • TargetMol | Compound LibraryMaltaMalta
  • TargetMol | Compound LibraryMoroccoMorocco
  • TargetMol | Compound LibraryNetherlandsNetherlands
  • TargetMol | Compound LibraryNew ZealandNew Zealand
  • TargetMol | Compound LibraryNorwayNorway
  • TargetMol | Compound LibraryPolandPoland
  • TargetMol | Compound LibraryPortugalPortugal
  • TargetMol | Compound LibraryRomaniaRomania
  • TargetMol | Compound LibrarySingaporeSingapore
  • TargetMol | Compound LibrarySlovakiaSlovakia
  • TargetMol | Compound LibrarySloveniaSlovenia
  • TargetMol | Compound LibrarySpainSpain
  • TargetMol | Compound LibrarySwedenSweden
  • TargetMol | Compound LibrarySwitzerlandSwitzerland
  • TargetMol | Compound LibraryTaiwan,ChinaTaiwan,China
  • TargetMol | Compound LibraryThailandThailand
  • TargetMol | Compound LibraryTurkeyTurkey
  • TargetMol | Compound LibraryUnited KingdomUnited Kingdom
  • TargetMol | Compound LibraryUnited StatesUnited States
  • TargetMol | Compound LibraryOther CountriesOther Countries
Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

DNA Alkylation

DNA alkylation refers to the addition of alkyl groups to specific bases, resulting in alkylation products such as O2‐alkylthymine, O4‐alkylthymine, O6‐methylguanine and O6‐ethylguanine, which cause DNA mutations.

  • Streptozocin
    T150718883-66-4
    Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation. Streptozocin is toxic to insulin-producing pancreatic islet B-cells and is commonly used in the construction of animal models of type 1 diabetes. The product is unstable in solution and is recommended to be dispensed now.
    • $30
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Phosphoramide mustard
    T3841010159-53-2
    Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage.
    • $293
    In Stock
    Size
    QTY
  • CEP-40125
    T269781456608-94-8In house
    CEP-40125 (RXDX-107) is a DNA alkylating agent for the study of advanced solid tumors.
    • $293 TargetMol
    In Stock
    Size
    QTY
  • DN-1289
    T73457 In house
    DN-1289 is an orally available, blood-brain barrier-crossing, selective and potent inhibitor with an IC50 value of 17 nM for di-leucine zipper kinase (DLK) and 40 nM for leucine zipper-bearing kinase (LZK).DN-1289 significantly inhibited optic nerve crush (ONC)-induced p-c-Jun in a mouse model.
    • $350
    In Stock
    Size
    QTY
  • Miriplatin hydrate
    T21297250159-48-9
    Miriplatin hydrate (SM-11355 (hydrate)) (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC). Miriplatin hydrate is a lipophilic platinum complex that can be easily suspended in Lipiodol and gradually releases active platinum compounds in tumor tissue.
    • $44
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • IACS-52825
    T793032640376-72-1In house
    IACS-52825 is a selective and potent dual leucine zipper kinase (DLK) inhibitor that reverses para-mechanical aberrant pain in a CIPN mouse model for the study of neurological disorders.
    • $195
    In Stock
    Size
    QTY
  • O6-Benzylguanine
    T753919916-73-5
    O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
    • $42
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Carmustine
    T3091154-93-8
    Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.
    • $40
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • VAL-083
    T1721223261-20-3
    VAL-083 is an alkylating agent with antitumor activity that produces N7 methylation on DNA.
    • $80
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • Tretazicar
    T679821919-05-1
    CB1954(Tretazicar (NSC-115829)), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent.
    • $47
    In Stock
    Size
    QTY
  • Methyl methanesulfonate
    T998566-27-3
    Methyl methanesulfonate is a DNA alkylator that modifies adenine (3-methyladenine) and guanine (7-methyladenine) respectively, resulting in base mismatch and replication disorders.
    • $29
    In Stock
    Size
    QTY
  • GNE-8505
    T114401620573-48-9
    GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
    • $920
    Backorder
    Size
    QTY
  • Seco-Duocarmycin SA
    T12813L144667-38-9
    Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
    • $2,270
    Backorder
    Size
    QTY
  • GNE-3511
    T37071496581-76-0
    GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
    • $45
    In Stock
    Size
    QTY
  • Altretamine
    T1241645-05-6
    Altretamine (ENT-50852) is an alkylating agent with antineoplastic activity.
    • $30
    In Stock
    Size
    QTY
  • Duocarmycin TM
    T11120157922-77-5
    Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
    • $158
    In Stock
    Size
    QTY
  • Busulfan
    T092355-98-1
    Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription.
    • $45
    In Stock
    Size
    QTY
  • DLK-IN-1
    T110561620574-24-4
    DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, retains excellent CNS permeability, and after multiple days of administration, its concentration
    • $523
    Backorder
    Size
    QTY
  • Chlorambucil
    T0975305-03-3
    Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.
    • $50
    In Stock
    Size
    QTY
  • URMC-099
    T60571229582-33-5
    URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
    • $52
    In Stock
    Size
    QTY
  • Lomustine
    T160113010-47-4
    Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors.
    • $50
    In Stock
    Size
    QTY
  • Satraplatin
    T7221129580-63-8
    Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.
    • $100
    In Stock
    Size
    QTY
  • Thio-TEPA
    T125052-24-4
    Thio-TEPA (Tiofosyl) is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
    • $31
    In Stock
    Size
    QTY
  • Palifosfamide
    T435031645-39-3
    Palifosfamide (Isophosphamide mustard) lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to 6.75 μM for most cell lines except OS222 (IC50=31.5 μM).
    • $70
    In Stock
    Size
    QTY
  • Lobaplatin
    T15771135558-11-1
    Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent which shows activity for a variety of tumour types and is a promising antitumour chemotherapeutic agent[1][2]. It is a platinum complex with DNA alkylating activity.
    • $89
    In Stock
    Size
    QTY
  • Duocarmycin Analog
    T19300372954-15-9
    Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.
    • $2,120
    Backorder
    Size
    QTY
  • Treosulfan
    T17159299-75-2
    Treosulfan (Treosulphan) is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
    • $34
    In Stock
    Size
    QTY
  • Lomeguatrib
    T2495192441-08-0
    Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
    • $43
    In Stock
    Size
    QTY