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Anti-IGF1R/CD221 Antibody (5P629)
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Catalog No. TMAY-00380
Alias JTK13, insulin-like growth factor 1 receptor, IGFR, IGFIR, IGF-I R, IGF1 Receptor, CD221
Anti-IGF1R/CD221 Antibody (5P629) is a Mouse antibody targeting IGF1R/CD221. Anti-IGF1R/CD221 Antibody (5P629) can be used in ELISA.
Anti-IGF1R/CD221 Antibody (5P629)
Anti-IGF1R/CD221 Antibody (5P629)
😃Good
Catalog No. TMAY-00380Alias JTK13, insulin-like growth factor 1 receptor, IGFR, IGFIR, IGF-I R, IGF1 Receptor, CD221
Anti-IGF1R/CD221 Antibody (5P629) is a Mouse antibody targeting IGF1R/CD221. Anti-IGF1R/CD221 Antibody (5P629) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA Reactivity: Human |
| Alias | JTK13, insulin-like growth factor 1 receptor, IGFR, IGFIR, IGF-I R, IGF1 Receptor, CD221 |
| Ig Type | Mouse IgG2a |
| Clone | 5P629 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IGF1R / CD221 extracellular domain (rhIGF1R; TMPY-00834; Met 1-Asn 932; NP_000866.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide-linked heterotetrameric transmembrane protein consisting of two α and two β subunits, and among which, the α subunit is extracellular while the β subunit has an extracellular domain, a transmembrane domain, and a cytoplasmic tyrosine kinase domain. The IGF1R signaling pathway is activated in the mammalian nervous system from the early developmental stages. Its major effect on developing neural cells is to promote their growth and survival. This pathway can integrate its action with signaling pathways of growth and morphogenetic factors that induce cell fate specification and selective expansion of specified neural cell subsets. Modulation of cell migration is another possible role that IGF1R activation may play in neurogenesis. In the mature brain, IGF-I binding sites have been found in different regions of the brain, and multiple reports confirmed a strong neuroprotective action of the IGF-IR against different pro-apoptotic insults. IGF1R is an important signaling molecule in cancer cells and plays an essential role in the establishment and maintenance of the transformed phenotype. Inhibition of IGF1R signaling thus appears to be a promising strategy to interfere with the growth and survival of cancer cells. IGF1R is frequently overexpressed by tumors and mediates proliferation and apoptosis protection. IGF signaling also influences hypoxia signaling, protease secretion, tumor cell motility, and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, IGF1R is now an attractive anti-cancer treatment target.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human IGF1R protein (TMPY-00834) |
| Antigen Species | Human |
| Biology Area | Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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