Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Acyltransferase

Acyltransferase is a type of transferase enzyme that acts upon acyl groups.

OSMI-1
T164091681056-61-0In house
OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans.
  • $34
In Stock
Size
QTY
TargetMol | Citations Cited
Avasimibe
T2753166518-60-1
Avasimibe (PD-148515) is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenzymes CYP2C9 1A2 2C19 (IC50: 2.9 13.9 26.5 μM).
  • $43
In Stock
Size
QTY
A 922500
T6365959122-11-3
A 922500 (DGAT-1 Inhibitor 4a) is an inhibitor of human and mouse DGAT-1 with IC50 values of 7 nM and 24 nM, respectively, demonstrating good selectivity over related acyltransferases, hERG, and a panel of anti-targets.
  • $45
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
TMP-153
T36126128831-46-9In house
TMP-153 is a novel and potent ACAT inhibitor with an IC50 value of 5-10 nM for intestinal and hepatic ACAT in animals.TMP-153 has a hypocholesterolemic effect, inhibiting cholesterol uptake and lowering plasma cholesterol in rats and hamsters.
  • $293 TargetMol
In Stock
Size
QTY
Xanthohumol
T33426754-58-1
Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows chemopreventive effects.
  • $61
In Stock
Size
QTY
Glabrol
TN169159870-65-4
5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA. It is an epigenetic modification formed by the action of DNA methyltransferases.
  • $73
In Stock
Size
QTY
PF-06424439 methanesulfonate
T124251469284-79-4
PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inhibition. It operates in a noncompetitive manner relative to the acyl-CoA substrate, marking its efficacy in targeting DGAT2.
  • $39
In Stock
Size
QTY
PF-04620110
T69371109276-89-2In house
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
  • $37
In Stock
Size
QTY
Monatepil maleate
T25828103379-03-9In house
Monatepil maleate (AJ-2615 maleate) is an orally active Ca2+-channel and α1-adrenoceptor antagonist and non-competitive heparanoyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor with antihypertensive activity.Monatepil maleate is used in studies of hyperlipidemia and atherosclerosis. Monatepil maleate is used to study hyperlipidemia and atherosclerosis.
  • $293
In Stock
Size
QTY
Nevanimibe hydrochloride
T12225L133825-81-7
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active, selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) with an EC50 of 9 nM.
  • $87
In Stock
Size
QTY
TargetMol | Inhibitor Sale
K-604 dihydrochloride
T11733217094-32-1
K-604 dihydrochloride, a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor, exhibits an IC50 of 0.45±0.06 μM.
  • $51
In Stock
Size
QTY
RP 70676
T12767136609-26-2
RP 70676 is a potent ACAT inhibitor(rat and rabbit ACAT with IC50 of 25 and 44 nM ).
  • $56
In Stock
Size
QTY
RU-SKI 43
T127971043797-53-0In house
RU-SKI 43 is a potent and selective hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. It exhibits anticancer activity and is a potential treatment for lung adenocarcinomas. RU-SKI 43 reduces Gli-1 activation through smoothening-independent non-canonical signaling and inhibits Akt and mTOR pathway activity.
  • $45
In Stock
Size
QTY
T863
T4681701232-20-4
T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. IC50 value: Target: DGAT1 T863 (DGAT-3) causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.
  • $32
In Stock
Size
QTY
Beauvericin
T1452326048-05-5
Beauvericin, a Fusarium mycotoxin, inhibits acyl-CoA:cholesterol acyltransferase (ACAT) in rat liver microsomal enzyme assays with an IC50 value of 3 μM.
  • $64
In Stock
Size
QTY
BAY-3827
T733502377576-35-5
BAY-3827 is a potent and selective AMPK inhibitor with potential antitumor activity, demonstrating antiproliferative effects in an androgen-dependent prostate cancer model and inhibiting the phosphorylation of acetyl CoA carboxylase 1 (ACC-1).
  • $51
In Stock
Size
QTY
Rimonabant
T1519L168273-06-1
Rimonabant (SR141716) is an inverse agonist for the cannabinoid receptor CB1. It is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. Its main avenue of effect is a reduction in appetite. Rimonabant is the first selective CB1 receptor blocker to be approved for use anywhere in the world. Rimonabant is approved in 38 countries including the E.U., Mexico, and Brazil. It was rejected for approval for use in the United States.
  • $42
In Stock
Size
QTY
TargetMol | Citations Cited
(R)-HTS-3
T843702771208-83-2
(R)-HTS-3, a lysophosphatidylcholinacyltransferase 3 (LPCAT3) inhibitor, remodels polyunsaturated phospholipid content in human cells and reduces RSL3-induced ferroptosis in cancer cells.
  • $195
In Stock
Size
QTY
10,12-Tricosadiynoic acid
T1003566990-30-5
10,12-Tricosadiynoic acid is a highly selective and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1), which can treat high-fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism.
  • $41
In Stock
Size
QTY
RP-64477
T8314135239-65-5
RP-64477 is the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT) inhibitor.
  • $61
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Eldacimibe
T31611141993-70-6In house
Eldacimibe (WAY-ACA-147) is an ACAT2 inhibitor for the treatment of cardiovascular disease and endocrine and metabolic disorders, study of atherosclerosis and hypercholesterolemia.
  • $146
In Stock
Size
QTY
YM17E
T13373124900-72-7
YM17E is an inhibitor of ACAT with IC50 of 44 nM in rabbit liver microsomes in vitro.
  • $55
In Stock
Size
QTY
Eflucimibe
T27245L202340-45-2In house
Eflucimibe (L0081) is an acyl coenzyme A: cholesterol acyltransferase inhibitor for the treatment of cardiovascular disease and endocrine and metabolic disorders, and can be used to study atherosclerosis and hyperlipidemia.
  • $195
In Stock
Size
QTY
PD 128042
T22665114289-47-3
PD 128042 (CI 976) is a potent, orally active, and selective ACAT inhibitor (IC50: 73 nM) as well as a lysophospholipid acyltransferase (LPAT) inhibitor. CI 976 inhibits Golgi-associated LPAT activity (IC50: 15 μM) and multiple membrane trafficking steps.
  • $43
In Stock
Size
QTY
TargetMol | Citations Cited
Cyclandelate
T0504456-59-7
Cyclandelate (BS 572), a direct-acting smooth muscle relaxant, is used to dilate blood vessels.
  • $42
In Stock
Size
QTY
Lecimibide
T25651130804-35-2In house
Lecimibide (DuP 128) is a potent and selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT), useful for studying high-lipid-related diseases.
  • $146
In Stock
Size
QTY
Monatepil 2maleate
T25828L In house
Monatepil 2maleate is an orally active Ca2+-channel antagonist and ACAT inhibitor with alpha(1)-adrenergic receptor blocking activity and antiarrhythmic properties that inhibit vasoconstriction.Monatepil 2maleate may be used to study atherosclerosis.
  • $195 TargetMol
In Stock
Size
QTY
VULM 1457
T23521228544-65-8
VULM 1457 is a potent ACAT inhibitor. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM1457 significantly reduces production and secretion of adrenomedullin (AM) and down-regulates AM receptors on human hepatoblastic cells.
  • $29
In Stock
Size
QTY
TargetMol | Inhibitor Sale
YM-750
T23550138046-43-2
YM-750 is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with an IC50 value of 0.18 μM. ACAT is an enzyme that catalyzes the conversion of cholesterol and long-chain fatty-acyl-coenzyme A into cholesteryl esters.
  • $32
In Stock
Size
QTY
TargetMol | Inhibitor Sale
RHC 80267
T823683654-05-1
RHC 80267 (U-57908) is a selective inhibitor of DAGL, with an IC50 of 4 μM in canine platelets.
  • $31
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Lateritin
T2563565454-13-9
Lateritin (Bassiatin) is An Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor and a platelet aggregation inhibitor from the mycelial cake of Gibberella lateritium. Bassiatin is the (3S,6R) isomer.
  • $258
In Stock
Size
QTY
ACAT-IN-1 cis isomer
T10503145961-79-1
ACAT-IN-1 cis isomer is a potent ACAT inhibitor (IC50: 100 nM) used for the study of immune system-related diseases.
  • $700
6-8 weeks
Size
QTY
Fumonisin B1
T15356116355-83-0
Fumonisin B1 (Fumonisin-B1) is a mycotoxin produced by Fusarium oxysporum that is widely present in crops, contaminating them and posing a significant food safety hazard.Fumonisin B1 is structurally a sphingosine and sphingomyelin analog, and inhibits the biosynthesis of complex sphingolipids through the inhibition of ceramidic synthases.
  • $298
35 days
Size
QTY
DL-Glyceraldehyde-3-phosphate
T37521591-59-3
DL-Glyceraldehyde-3-phosphate (3-Phosphoglyceraldehyde) is an important intermediate in glycogen or starch fermentation in organisms and inhibits acyltransferases. DL-Glyceraldehyde-3-phosphate inhibits the growth of Escherichia coli at high concentrations.
  • $88
35 days
Size
QTY
BMS-963272
T389221441057-15-3
BMS-963272 is a selective and potent MGAT2 inhibitor with an IC50 value of 7.1 nM used in the study of metabolic disorders and obesity.
    Inquiry
    PF-07202954
    T797642639372-47-5
    PF-07202954, a weakly basic diacylglycerol O-acyltransferase 2 (DGAT2) inhibitor, exhibits an inhibition concentration half-maximum (IC50) of 10 nM against human DGAT2 and effectively reduces liver triglyceride content in a rat model fed on a Western diet [1].
    • $5,859
    10-14 weeks
    Size
    QTY
    DGAT2-IN-3
    T2007473037141-61-7
    DGAT2-IN-3 (compound 9) is an inhibitor of DGAT2 with an IC50 value of 0.4 nM. It is utilized in research related to fatty liver disease, diabetes, and cardiovascular diseases.
    • Inquiry Price
    10-14 weeks
    Size
    QTY
    24-Methylenecholesterol
    T29329474-63-5
    24-Methylenecholesterol (24 Methylenecholesterol) is a natural marine sterol, which stimulates cholesterol acyl transferase (ACAT) in human macrophages.
    • $1,218
    Backorder
    Size
    QTY
    PF-06424439
    T124261469284-78-3
    PF-06424439 is an oral and selective inhibitor of imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) (IC50 of 14 nM).
    • $1,670
    1-2 weeks
    Size
    QTY
    BMS-986172
    T828481808258-99-2
    BMS-986172 is an orally active, highly selective inhibitor of MGAT2, with inhibitory concentrations (IC50) of 4.6 nM for human MGAT2 (hMGAT2) and 20 nM for mouse MGAT2 (mMGAT2). It exhibits an in vitro half-life (T1 2) greater than 120 minutes and is known to decrease food intake and body weight. This compound is promising for research in metabolic disorders, including obesity and non-alcoholic steatohepatitis (NASH) [1].
    • Inquiry Price
    8-10 weeks
    Size
    QTY
    Diacylglycerol acyltransferase inhibitor-2
    T898522186700-48-9
    Diacylglycerolacyltransferaseinhibitor-2 (Example 8) acts as an inhibitor for diacylglycerol acyltransferase 2 (DGAT2), exhibiting an IC50 value of 3.7 nM.
    • Inquiry Price
    10-14 weeks
    Size
    QTY