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TargetMol | Tags Metabolism
ANGPTL
(4)
ATP Citrate Lyase
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Acetyl-CoA Carboxylase
(32)
Aconitase
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Acyltransferase
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Adenosine Deaminase
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AhR
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Aminopeptidase
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Amylase
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Angiotensin-converting Enzyme (ACE)
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Apolipoprotein
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Calcium Channel
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Carbonic Anhydrase
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Casein Kinase
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Cytochromes P450
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Decarboxylase
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Dehydrogenase
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Drug Metabolite
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Endogenous Metabolite
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FAAH
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Factor VIII
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Fatty Acid Synthase
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GSNOR
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Glucokinase
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Glucosidase
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Glyoxalase
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HIF/HIF Prolyl-Hydroxylase
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HMG-CoA Reductase
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HSP
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Hydrogenase
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Hydroxylase
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IDO
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Indoleamine 2,3-Dioxygenase (IDO)
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Isocitrate Dehydrogenase (IDH)
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LDL
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Lipid
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Liposome
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Lipoxygenase
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MAO
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N-Acetylglucosaminyltransferase
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Serine/threonin kinase
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Transferase
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UGT
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Vitamin
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Xanthine Oxidase
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glycosidase
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hCE
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stilbene oxidase
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transporter
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Acyltransferase

Acyltransferase is a type of transferase enzyme that acts upon acyl groups.

OSMI-4
T123282260791-14-6In house
OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor (EC50 of 3 μM in cells) that can be used to study OGT inhibition in different human cell lines.
  • $215
In Stock
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QTY
TargetMol | Inhibitor Hot
Xanthohumol
T33426754-58-1
Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows chemopreventive effects.
  • $61
In Stock
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OSMI-1
T164091681056-61-0In house
OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans.
  • $34
In Stock
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TargetMol | Citations Cited
Avasimibe
T2753166518-60-1
Avasimibe (PD-148515) is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenzymes CYP2C9/1A2/2C19 (IC50: 2.9/13.9/26.5 μM).
  • $43
In Stock
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PF-06424439 methanesulfonate
T124251469284-79-4
PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inhibition. It operates in a noncompetitive manner relative to the acyl-CoA substrate, marking its efficacy in targeting DGAT2.
  • $39
In Stock
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A 922500
T6365959122-11-3
A 922500 (DGAT-1 Inhibitor 4a) is an inhibitor of human and mouse DGAT-1 with IC50 values of 7 nM and 24 nM, respectively, demonstrating good selectivity over related acyltransferases, hERG, and a panel of anti-targets.
  • $41
In Stock
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TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Glabrol
TN169159870-65-4
5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA. It is an epigenetic modification formed by the action of DNA methyltransferases.
  • $73
In Stock
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OSMI-3
T123272260791-13-5In house
OSMI-3 is a potent and cell-permeable inhibitor of O-GlcNAc transferase (OGT) for the study of cancer and cardiovascular disease.
  • $397
In Stock
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K-604 dihydrochloride
T11733217094-32-1
K-604 dihydrochloride, a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor, exhibits an IC50 of 0.45±0.06 μM.
  • $51
In Stock
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ACAT-IN-1 cis isomer
T10503145961-79-1In house
ACAT-IN-1 cis isomer is a potent ACAT inhibitor (IC50: 100 nM) used for the study of immune system-related diseases.
  • $700
In Stock
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BAY-3827
T733502377576-35-5
BAY-3827 is a potent and selective AMPK inhibitor with potential antitumor activity, demonstrating antiproliferative effects in an androgen-dependent prostate cancer model and inhibiting the phosphorylation of acetyl CoA carboxylase 1 (ACC-1).
  • $51
In Stock
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Monatepil maleate
T25828103379-03-9In house
Monatepil maleate (AJ-2615 maleate) is an orally active Ca2+-channel and α1-adrenoceptor antagonist and non-competitive heparanoyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor with antihypertensive activity.Monatepil maleate is used in studies of hyperlipidemia and atherosclerosis. Monatepil maleate is used to study hyperlipidemia and atherosclerosis.
  • $293
In Stock
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RU-SKI 43
T127971043797-53-0In house
RU-SKI 43 is a potent and selective hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. It exhibits anticancer activity and is a potential treatment for lung adenocarcinomas. RU-SKI 43 reduces Gli-1 activation through smoothening-independent non-canonical signaling and inhibits Akt and mTOR pathway activity.
  • $45
8-10 weeks
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Nevanimibe hydrochloride
T12225L133825-81-7
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active, selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) with an EC50 of 9 nM.
  • $87
In Stock
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TargetMol | Inhibitor Sale
OGT-IN-2
T9711442665-87-4
OGT-IN-2 is a potent O-GlcNAc transferase (OGT) inhibitor. OGT-IN-2 inhibits sOGT and ncOGT with IC50 values of 30 μM and 53 μM, respectively[1]. OGT-IN-2 can be used for the research of articular diseases[1].
  • $68
In Stock
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PF-04620110
T69371109276-89-2In house
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
  • $37
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T863
T4681701232-20-4
T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. IC50 value: Target: DGAT1 T863 (DGAT-3) causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.
  • $32
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TMP-153
T36126128831-46-9In house
TMP-153 is a novel and potent ACAT inhibitor with an IC50 value of 5-10 nM for intestinal and hepatic ACAT in animals.TMP-153 has a hypocholesterolemic effect, inhibiting cholesterol uptake and lowering plasma cholesterol in rats and hamsters.
  • $293 TargetMol
In Stock
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Zamaporvint
T777801900754-56-4
Zamaporvint (RXC004) is a selective, orally active and potent inhibitor of the Wnt pathway that acts on the membrane-bound fatty acyltransferase porcupine to block Wnt ligand palmitoylation, secretion, and pathway activation.Zamaporvint has shown anti-tumor and anti-proliferative activity in a wide range of cancer cell lines.
  • $87
In Stock
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(R)-HTS-3
T843702771208-83-2
(R)-HTS-3, a lysophosphatidylcholinacyltransferase 3 (LPCAT3) inhibitor, remodels polyunsaturated phospholipid content in human cells and reduces RSL3-induced ferroptosis in cancer cells.
  • $68
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Rimonabant
T1519L168273-06-1
Rimonabant (SR141716) is an inverse agonist for the cannabinoid receptor CB1. It is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. Its main avenue of effect is a reduction in appetite. Rimonabant is the first selective CB1 receptor blocker to be approved for use anywhere in the world. Rimonabant is approved in 38 countries including the E.U., Mexico, and Brazil. It was rejected for approval for use in the United States.
  • $42
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TargetMol | Citations Cited
Beauvericin
T1452326048-05-5
Beauvericin, a Fusarium mycotoxin, inhibits acyl-CoA:cholesterol acyltransferase (ACAT) in rat liver microsomal enzyme assays with an IC50 value of 3 μM.
  • $64
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10,12-Tricosadiynoic acid
T1003566990-30-5
10,12-Tricosadiynoic acid is a highly selective and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1), which can treat high-fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism.
  • $41
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BMS-963272
T389221441057-15-3
BMS-963272 is a selective and potent MGAT2 inhibitor with an IC50 value of 7.1 nM used in the study of metabolic disorders and obesity.
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