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Rho-Kinase-IN-1

Name: Rho-Kinase-IN-1
Brand: TargetMol
SKU: T12721
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12721Cas No. 1035094-83-7

Rho-Kinase-IN-1 is an inhibitor of ROCK with Kis of 30.5 nM and 3.9 nM for ROCK1 and ROCK2, respectively. Rho-Kinase-IN-1 can be used in studies about excessive cell proliferation, remodeling, edema and inflammation diseases.

Rho-Kinase-IN-1

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Purity: 99.8%

Catalog No. T12721Cas No. 1035094-83-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	In Stock	In Stock
5 mg	$148	In Stock	In Stock
10 mg	$227	In Stock	In Stock
25 mg	$397	In Stock	In Stock
50 mg	$557	In Stock	In Stock
100 mg	$738	In Stock	In Stock
200 mg	$993	-	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.8%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Rho-Kinase-IN-1 AI Summary

Rho-Kinase-IN-1 exhibits bioactivity as a kinase inhibitor, specifically targeting ROCK2 (Rho-associated protein kinase 2). It has demonstrated significant potency in inhibiting ROCK2 activity, with an IC50 value of 65.8 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Rho-Kinase-IN-1 is an inhibitor of ROCK with Kis of 30.5 nM and 3.9 nM for ROCK1 and ROCK2, respectively. Rho-Kinase-IN-1 can be used in studies about excessive cell proliferation, remodeling, edema and inflammation diseases.
Targets&IC50	ROCK1:30.5 nM (ki), ROCK2:3.9 nM (ki)

Chemical Properties

Molecular Weight	352.5
Formula	C₂₀H₂₄N₄S
Cas No.	1035094-83-7
Smiles	CSc1ccc(CN2CCCC(C2)Nc2ccc3[nH]ncc3c2)cc1
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (184.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8369 mL	14.1844 mL	28.3688 mL	141.8440 mL
5 mM	0.5674 mL	2.8369 mL	5.6738 mL	28.3688 mL
10 mM	0.2837 mL	1.4184 mL	2.8369 mL	14.1844 mL
20 mM	0.1418 mL	0.7092 mL	1.4184 mL	7.0922 mL
50 mM	0.0567 mL	0.2837 mL	0.5674 mL	2.8369 mL
100 mM	0.0284 mL	0.1418 mL	0.2837 mL	1.4184 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc