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Sodium gualenate

Name: Sodium gualenate
Brand: TargetMol
SKU: T7116
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7116Cas No. 6223-35-4

Alias Guaiazulenesulfonate sodium

Sodium gualenate (Guaiazulenesulfonate sodium) (Guaiazulenesulfonate sodium), a hydrophilic derivative of guaiazulene (GA), is an unstable compound. It has anti-inflammatory and wound-healing effects.

Sodium gualenate

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Purity: 99.70%

Catalog No. T7116Alias Guaiazulenesulfonate sodiumCas No. 6223-35-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	In Stock	-
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.70%

Appearance:Solid

Color:Blue

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Sodium gualenate (Guaiazulenesulfonate sodium) (Guaiazulenesulfonate sodium), a hydrophilic derivative of guaiazulene (GA), is an unstable compound. It has anti-inflammatory and wound-healing effects.
In vivo	Sodium gualenate is frequently used to treat human gastritis, with its primary mechanism of action being the cytoprotection of the stomach's mucosal lining [1].
Animal Research	The anti-gastric ulcer activity of compounds was tested through an ethanol-induced gastric ulcer mouse model method.?Kunming mice, consisting of both males and females, each weighing about 25 g, were divided into groups of 8 at random.?The tested compounds, Omeprazole and guaiazulene derivatives which were made into suspensions using 5% CMC-Na were administered orally (0.4 mL/20 g) to the dose group, the drug reference group and the GAS-Na group respectively.?While the base control group was treated with only 5% CMC-Na.?Vehicle or test compounds were administered by the oral route once a day for five consecutive days.?After 0.5 h of the last dose, the mice were given orally 0.3 mL of anhydrous ethanol.?Half an hour after anhydrous ethanol administration, the animals were killed.?At last, the stomachs were removed and scored[1].
Synonyms	Guaiazulenesulfonate sodium

Chemical Properties

Molecular Weight	300.35
Formula	C₁₅H₁₇NaO₃S
Cas No.	6223-35-4
Smiles	[Na+].CC(C)c1ccc(C)c2c(cc(C)c2c1)S([O-])(=O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (99.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.66 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3294 mL	16.6472 mL	33.2945 mL	166.4724 mL
5 mM	0.6659 mL	3.3294 mL	6.6589 mL	33.2945 mL
10 mM	0.3329 mL	1.6647 mL	3.3294 mL	16.6472 mL
20 mM	0.1665 mL	0.8324 mL	1.6647 mL	8.3236 mL
50 mM	0.0666 mL	0.3329 mL	0.6659 mL	3.3294 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc