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Trifluoperazine dihydrochloride

Name: Trifluoperazine dihydrochloride
Brand: TargetMol
SKU: T1222
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1222Cas No. 440-17-5

Alias Urinox, Trifluoperazine 2HCl, SKF5019

Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.

Trifluoperazine dihydrochloride

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Purity: 99.96%

Catalog No. T1222Alias Urinox, Trifluoperazine 2HCl, SKF5019Cas No. 440-17-5

Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.

Pack Size	Price	Availability	Quantity
100 mg	$50	In Stock

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Purity:99.96%

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Product Introduction

Bioactivity

Description	Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
Targets&IC50	D2 receptor:1.1 nM
In vitro	Trifluoperazine binds to α1A- and α1B-adrenoceptor with Ki value of 27.6 nM and 19.2 nM, respectively, with α1B/α1A ratio of 0.7. [2] Trifluoperazine inhibits Mycobacterium tuberculosis (Mtb) with MICs of 7.6 μg/mL. [3] Trifluoperazine (< 14.78 mM) suppresses the activities of the mouse splenic NK cell cytotoxicity and the effector-target cell conjugation in a dose dependent manner. Trifluoperazine suppresses interferon-alpha or interleukin-2 induced augmentation of the cytolytic activity of NK cells. [4] Trifluoperazine inhibits the gene expression of voltage-dependent potassium channel Kv2.1 from human brain (hKv2.1). [5]
In vivo	Trifluoperazine dose dependently decreases avoidance responses and increases response failures in rats where behavior is maintained under a discrete-trial avoidance. [6]
Synonyms	Urinox, Trifluoperazine 2HCl, SKF5019

Chemical Properties

Molecular Weight	480.43
Formula	C₂₁H₂₆Cl₂F₃N₃S
Cas No.	440-17-5
Smiles	Cl.CN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 88 mg/mL (183.17 mM), Sonication is recommended.

DMSO: 82 mg/mL (170.68 mM), Sonication is recommended.

Ethanol: 89 mg/mL (185.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.0815 mL	10.4073 mL	20.8147 mL	104.0734 mL
5 mM	0.4163 mL	2.0815 mL	4.1629 mL	20.8147 mL
10 mM	0.2081 mL	1.0407 mL	2.0815 mL	10.4073 mL
20 mM	0.1041 mL	0.5204 mL	1.0407 mL	5.2037 mL
50 mM	0.0416 mL	0.2081 mL	0.4163 mL	2.0815 mL
100 mM	0.0208 mL	0.1041 mL	0.2081 mL	1.0407 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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Trifluoperazine dihydrochloride

Trifluoperazine dihydrochloride

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