IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 μg | 5 days | $ 487.00 | |
500 μg | 5 days | $ 1,950.00 | |
1 mg | 5 days | $ 3,250.00 |
Description | IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. |
Species | Human |
Expression System | HEK293 |
Tag | C-hFc |
Accession Number | P01562 |
Synonyms | IFN-α-1/13, IFN α1, IFN alpha1, IFNA1, IFN α 1, IFNalpha 1, Interferon alpha 1, Interferon alpha-1/13, Interferon α1, Interferon α-D, Interferon α-1/13, LeIF D, IFN-alpha-1, IFNα1, IFN-α-1, Interferon alpha-D, IFN-alpha-1/13 |
Construction | Recombinant Human IFN alpha 1 Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Cys24-Glu189.[Accession |P01562] |
Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
Molecular Weight | The protein has a predicted MW of 46.14 kDa. Due to glycosylation, the protein migrates to 48-55 kDa based on Tris-Bis PAGE result. |
Endotoxin | Less than 1EU per μg by the LAL method. |
Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability & Storage |
-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. |
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IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc) IFN-α-1/13 IFNA 1 IFN α1 Interferon a 1 IFN alpha1 IFNA1 IFN α 1 IFNalpha 1 IFN-a-1/13 Interferon alpha 1 Interferon alpha-1/13 IFN-a-1 Interferon α1 Interferon a-D Interferon α-D IFNA-1 Interferon α-1/13 LeIF D IFN-alpha-1 IFNα1 IFN-α-1 Interferon α 1 Interferon alpha-D Interferon a-1/13 IFN-alpha-1/13 IFNα 1 recombinant recombinant-proteins proteins protein